سعر جراموفلوكس 500/500 مجم 16 قرص 2022

Amoxicillin 500 mg + flucloxacillin 500 mg film-coated tablets, 16 tablets per pack.

• US (amoxicillin): the most common adverse reactions are diarrhoea, rash, vomiting and nausea.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• UK (flucloxacillin): minor gastrointestinal disturbances are common; rash and urticaria are uncommon; hepatitis and cholestatic jaundice are very rare.General active-ingredient information · electronic medicines compendium (emc), UK

• US (amoxicillin): history of serious hypersensitivity (e.g. anaphylaxis or Stevens-Johnson syndrome) to amoxicillin or other beta-lactams.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• UK (flucloxacillin): hypersensitivity to beta-lactam antibiotics; previous history of flucloxacillin-associated jaundice or hepatic dysfunction.General active-ingredient information · electronic medicines compendium (emc), UK

• US (amoxicillin): anaphylaxis and severe cutaneous adverse reactions can occur; C. difficile-associated diarrhoea has been reported; avoid in infectious mononucleosis because of a high rate of erythematous rash.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• UK (flucloxacillin): hepatitis and cholestatic jaundice may occur, more often in patients over 50 and with prolonged treatment, and may be delayed up to two months after stopping; acute generalised exanthematous pustulosis has been reported.General active-ingredient information · electronic medicines compendium (emc), UK
• UK (flucloxacillin): risk of high anion gap metabolic acidosis when used with paracetamol, particularly in patients with risk factors; hypokalaemia may occur; caution in neonates (hyperbilirubinaemia).General active-ingredient information · electronic medicines compendium (emc), UK

• ProbenecidUS/UK: probenecid decreases renal tubular secretion of amoxicillin and flucloxacillin, increasing their blood levels.DailyMed (U.S. National Library of Medicine), electronic medicines compendium (emc), UK
• Oral anticoagulants (warfarin)US (amoxicillin): abnormal prolongation of prothrombin time/INR may occur; UK (flucloxacillin): may alter the INR response to warfarin. Monitor INR.DailyMed (U.S. National Library of Medicine), electronic medicines compendium (emc), UK
• ParacetamolUK (flucloxacillin): concomitant use is associated with high anion gap metabolic acidosis; close monitoring recommended.electronic medicines compendium (emc), UK
• MethotrexateUK (flucloxacillin): penicillins reduce methotrexate excretion, increasing the risk of toxicity.electronic medicines compendium (emc), UK
• VoriconazoleUK (flucloxacillin): may significantly decrease voriconazole plasma concentrations.electronic medicines compendium (emc), UK

• US (amoxicillin): historical FDA category B; use in pregnancy only if clearly needed. UK (flucloxacillin): use in pregnancy only when the potential benefits outweigh the possible risks.General active-ingredient information · DailyMed (U.S. National Library of Medicine), electronic medicines compendium (emc), UK
• US (amoxicillin): excreted in human milk and may lead to sensitisation of the infant; UK (flucloxacillin): trace amounts in breast milk, possibility of hypersensitivity in the infant.General active-ingredient information · DailyMed (U.S. National Library of Medicine), electronic medicines compendium (emc), UK

• Amoxicillin: Bactericidal beta-lactam that inhibits bacterial cell-wall biosynthesis during active multiplication; inactivated by beta-lactamases (US label, section 12.4).
• Flucloxacillin: Isoxazolyl penicillin of the beta-lactam group with bactericidal activity against many Gram-positive organisms, including beta-lactamase-producing staphylococci and streptococci (UK SmPC).