سعر اميوران 50مجم 100 قرص 2024

Imuran 50 mg film-coated tablets (pack of 100, 4 strips): azathioprine, a purine antimetabolite immunosuppressant; listed by Egyptian directories as manufactured by Excella GmbH (Germany) for GlaxoSmithKline.

• Adjunct for the prevention of rejection in renal homotransplantation.Population: Renal transplant recipientsDailyMed (U.S. National Library of Medicine)
• Management of active rheumatoid arthritis to reduce signs and symptoms.Population: Adults with rheumatoid arthritisDailyMed (U.S. National Library of Medicine)

• Principal serious toxicities are hematologic (leukopenia, thrombocytopenia) and gastrointestinal (nausea, vomiting); secondary infection and malignancy are significant risks.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to azathioprine.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Must not be used to treat rheumatoid arthritis in pregnant women.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Rheumatoid arthritis patients previously treated with alkylating agents (cyclophosphamide, chlorambucil, melphalan) may have a prohibitive risk of malignancy.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: chronic immunosuppression increases the risk of malignancy, including post-transplant lymphoma and hepatosplenic T-cell lymphoma in inflammatory bowel disease.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Severe leukopenia, thrombocytopenia, anemias and pancytopenia may occur; patients with low or absent TPMT or NUDT15 activity are at increased risk of severe myelotoxicity.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Increased risk of serious infections, including progressive multifocal leukoencephalopathy (PML).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Allopurinol / febuxostat (xanthine oxidase inhibitors)With allopurinol reduce azathioprine to about one-third to one-quarter of the usual dose; use with febuxostat is not recommended.DailyMed (U.S. National Library of Medicine)
• Aminosalicylates (sulfasalazine, mesalazine, olsalazine)May inhibit TPMT; use concomitantly with caution.DailyMed (U.S. National Library of Medicine)
• Co-trimoxazole and other drugs affecting myelopoiesisMay cause exaggerated leukopenia, especially in renal transplant recipients.DailyMed (U.S. National Library of Medicine)

• Azathioprine can cause fetal harm; avoid use in pregnancy whenever possible and do not use it to treat rheumatoid arthritis in pregnant women; teratogenic in rabbits and mice.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Use in nursing mothers is not recommended; azathioprine or its metabolites pass into breast milk at low levels.International label, same formulation · DailyMed (U.S. National Library of Medicine)

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