سعر انتاكسيل 6 مجم / مل 100 مجم فيال 2022

Intaxel: paclitaxel 6 mg/ml concentrate for intravenous infusion, 100 mg per vial (Fresenius Kabi; imported via Egyptian Group for Import and Export). For use under the supervision of an experienced oncologist.

• Ovarian cancer: first-line therapy in combination with cisplatin, and subsequent therapy of advanced ovarian carcinoma.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Breast cancer: adjuvant treatment of node-positive breast cancer administered sequentially after standard doxorubicin-containing combination chemotherapy.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Breast cancer: metastatic disease after failure of combination chemotherapy or relapse within 6 months of adjuvant chemotherapy (prior therapy should have included an anthracycline unless contraindicated).Population: AdultsDailyMed (U.S. National Library of Medicine)

• Single-agent data in solid tumours: neutropenia below 2,000 cells/mm3 (90%), anaemia (78%), infections (30%), hypersensitivity reactions (41%; severe 2%), peripheral neuropathy (60%), myalgia/arthralgia (60%), nausea and vomiting (52%), diarrhoea (38%), mucositis (31%), alopecia (87%).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• History of hypersensitivity reactions to paclitaxel or other drugs formulated in polyoxyl 35 castor oil.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Solid tumours with baseline neutrophil counts below 1,500 cells/mm3, or AIDS-related Kaposi's sarcoma with baseline neutrophils below 1,000 cells/mm3.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: administer under the supervision of a physician experienced in cancer chemotherapy. Anaphylaxis and severe hypersensitivity reactions (dyspnoea and hypotension requiring treatment, angioedema, generalized urticaria) occurred in 2-4% of patients; fatal reactions occurred despite premedication. Patients with severe reactions should not be rechallenged.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Bone marrow suppression (primarily neutropenia) is the dose-limiting toxicity; frequent peripheral blood counts are required. Severe cardiac conduction abnormalities have been reported; peripheral neuropathy is frequent. Injection-site reactions, including extravasation, can occur.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• The US product contains 49.7% (v/v) dehydrated alcohol and 527 mg/mL polyoxyl 35 castor oil; overdoses in pediatric patients may be associated with acute ethanol toxicity.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• CisplatinWhen paclitaxel was given after cisplatin, myelosuppression was more profound and paclitaxel clearance fell by about 33%; paclitaxel should be given before cisplatin.DailyMed (U.S. National Library of Medicine)
• Inhibitors or inducers of CYP2C8 or CYP3A4Paclitaxel is metabolised by CYP2C8 and CYP3A4; use caution with known substrates, inhibitors or inducers of these enzymes.DailyMed (U.S. National Library of Medicine)

• Paclitaxel can cause fetal harm when administered to a pregnant woman (embryo- and fetotoxic in animals); women of childbearing potential should avoid becoming pregnant during therapy. The label uses the pre-PLLR format and lists Pregnancy Category D.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• It is not known whether paclitaxel is excreted in human milk; nursing should be discontinued during therapy.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Paclitaxel: Promotes assembly of microtubules from tubulin dimers and stabilises them by preventing depolymerisation, inhibiting the normal dynamic reorganisation of the microtubule network needed for mitosis.