سعر لاستليرج 10مجم 14 قرص 2024

Lastlerge mizolastine 10 mg scored modified-release film-coated tablets, pack of 14 (Medizen Pharmaceutical Industries, Egypt); long-acting H1 antihistamine.

• Symptomatic treatment of seasonal and perennial allergic rhinoconjunctivitis and urticaria.Population: Adults and children aged 12 years and overIsrael Ministry of Health (Israeli Drug Registry)

• Common: dry mouth, diarrhoea, abdominal pain/dyspepsia, nausea, drowsiness (often transient), headache, dizziness, asthenia, increased appetite with weight gain. Uncommon: anxiety, depression, raised liver enzymes, hypotension, tachycardia, palpitations, arthralgia, myalgia. Very rare: low neutrophil count, allergic reactions including anaphylaxis and angioedema.International label, same formulation · Israel Ministry of Health (Israeli Drug Registry)

• Hypersensitivity; concomitant macrolide antibiotics or systemic imidazole antifungals; significantly impaired hepatic function; clinically significant cardiac disease or history of symptomatic arrhythmias; known or suspected QT prolongation or electrolyte imbalance (especially hypokalaemia); clinically significant bradycardia; drugs known to prolong QT (class I and III antiarrhythmics).International label, same formulation · Israel Ministry of Health (Israeli Drug Registry)

• Weak potential to prolong the QT interval in a few individuals; contains lactose (not for hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption) and hydrogenated castor oil (may cause stomach upset and diarrhoea); check individual response before driving.International label, same formulation · Israel Ministry of Health (Israeli Drug Registry)

• Ketoconazole, erythromycin (systemic imidazole antifungals and macrolides)Moderately increase mizolastine plasma concentration; concurrent use is contraindicated.Israel Ministry of Health (Israeli Drug Registry)
• Cimetidine, ciclosporin, nifedipine (CYP3A4 inhibitors or substrates)Concurrent use should be approached with caution.Israel Ministry of Health (Israeli Drug Registry)
• AlcoholNo potentiation of alcohol-induced sedation or performance impairment was observed in studies.Israel Ministry of Health (Israeli Drug Registry)

• Safety in human pregnancy not established; animal studies show no direct or indirect harmful effects, but as with all medicines mizolastine should be avoided in pregnancy, particularly during the first trimester.International label, same formulation · Israel Ministry of Health (Israeli Drug Registry)
• Mizolastine is excreted into breast milk; use by lactating women is not recommended.International label, same formulation · Israel Ministry of Health (Israeli Drug Registry)

• Mizolastine: Specific, selective antagonist of peripheral histamine H1 receptors; also inhibits histamine release from mast cells and neutrophil migration in animal models (SmPC 5.1).