سعر ماجيكلاستين 10مجم 20اقراص 2022

Magiclastine 10 mg film-coated tablets (Medizen / Magic Pharma), pack of 20: mizolastine, a long-acting second-generation H1 antihistamine for allergic rhinoconjunctivitis and urticaria.

• Symptomatic treatment of seasonal allergic rhinoconjunctivitis (hay fever), perennial allergic rhinoconjunctivitis and urticaria.Population: Adults (including elderly) and children over 12 yearsBase de données publique des médicaments (ANSM, France)

• Common: dry mouth, diarrhoea, abdominal pain (including dyspepsia), nausea, often transient drowsiness, headache, dizziness, asthenia, increased appetite with weight gain.International label, equivalent formulation · Base de données publique des médicaments (ANSM, France)
• Uncommon: anxiety, depression, raised liver enzymes, hypotension, tachycardia, palpitations, arthralgia and myalgia. Very rare: neutropenia, allergic reactions (anaphylaxis, angioedema, rash, urticaria, pruritus), vasovagal malaise up to syncope.International label, equivalent formulation · Base de données publique des médicaments (ANSM, France)

• Hypersensitivity to the active substance or any excipient.International label, equivalent formulation · Base de données publique des médicaments (ANSM, France)
• Concomitant systemic macrolide antibiotics or systemic imidazole antifungals.International label, equivalent formulation · Base de données publique des médicaments (ANSM, France)
• Significant impairment of hepatic function.International label, equivalent formulation · Base de données publique des médicaments (ANSM, France)

• Mizolastine has a weak potential to prolong the QT interval, seen only in a few cases; the prolongation was modest and not associated with arrhythmias.International label, equivalent formulation · Base de données publique des médicaments (ANSM, France)
• Contains lactose (not for hereditary galactose intolerance, total lactase deficiency or glucose-galactose malabsorption) and hydrogenated castor oil (may cause stomach upset and diarrhoea).International label, equivalent formulation · Base de données publique des médicaments (ANSM, France)
• Most patients can drive, but individual response should be checked before driving or complex tasks.International label, equivalent formulation · Base de données publique des médicaments (ANSM, France)

• Ketoconazole, erythromycin and other systemic imidazole antifungals or macrolidesModerately increase mizolastine plasma concentrations; combination is contraindicated.Base de données publique des médicaments (ANSM, France)
• Potent CYP3A4 inhibitors or substrates (e.g. cimetidine, ciclosporin, nifedipine)Use the combination only with caution.Base de données publique des médicaments (ANSM, France)
• Drugs that prolong the QT interval (e.g. class I and III antiarrhythmics)Contraindicated.Base de données publique des médicaments (ANSM, France)

• Safety in pregnancy is not established; animal studies show no direct or indirect harmful effects, but as a precaution mizolastine should be avoided during pregnancy, particularly in the first trimester.International label, equivalent formulation · Base de données publique des médicaments (ANSM, France)
• Mizolastine is excreted in breast milk; its use is not recommended during breastfeeding.International label, equivalent formulation · Base de données publique des médicaments (ANSM, France)

• Mizolastine: Specific, selective blockade of peripheral histamine H1 receptors; in animal models it also inhibits histamine release from mast cells and neutrophil migration. Onset is rapid and the effect lasts 24 hours; no anticholinergic effect was found.