سعر لو استيرول 10مجم 20 قرص 2022

Simvastatin 10 mg film-coated tablets (T3A Pharma, Egypt); HMG-CoA reductase inhibitor.

• To reduce the risk of total mortality, coronary heart disease death, non-fatal MI, stroke and revascularization in adults at high risk of coronary eventsPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Adjunct to diet to reduce LDL-C in adults with primary hyperlipidemia and in adults and children 10 years and older with heterozygous familial hypercholesterolemiaPopulation: Adults and children >= 10 yearsDailyMed (U.S. National Library of Medicine)

• Most common (>= 5%): upper respiratory infection, headache, abdominal pain, constipation and nausea.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Concomitant use of strong CYP3A4 inhibitors (select azole antifungals, macrolide antibiotics, antivirals, nefazodone).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Concomitant use of cyclosporine, danazol or gemfibrozil.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Acute liver failure or decompensated cirrhosis.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Myopathy and rhabdomyolysis: risk factors include age 65 or older, uncontrolled hypothyroidism, renal impairment, interacting drugs and higher doses; discontinue if CK is markedly elevated or myopathy is suspected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Immune-mediated necrotizing myopathy has been reported; hepatic dysfunction may occur (check liver enzymes as clinically indicated); increases in HbA1c and fasting glucose have been reported.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Coumarin anticoagulantsObtain INR before initiation and monitor during initiation or dose adjustment.DailyMed (U.S. National Library of Medicine)
• DigoxinMonitor digoxin levels during initiation.DailyMed (U.S. National Library of Medicine)
• Strong CYP3A4 inhibitors, cyclosporine, danazol, gemfibrozilContraindicated (increased risk of myopathy/rhabdomyolysis).DailyMed (U.S. National Library of Medicine)

• Discontinue when pregnancy is recognized, or consider the ongoing therapeutic needs of the patient; may cause fetal harm based on mechanism of action.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Breastfeeding is not recommended during treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Simvastatin: Prodrug hydrolysed to simvastatin acid, which inhibits HMG-CoA reductase, the rate-limiting enzyme of cholesterol synthesis, increasing LDL-receptor expression.