سعر سيمفاكور 40مجم 7 اقراص 2022

Simvacor 40 mg film-coated tablets (simvastatin), pack of 7, by Sigma; an HMG-CoA reductase inhibitor (statin).

• To reduce the risk of total mortality, coronary heart disease death, non-fatal MI and stroke, and need for revascularization in adults with established coronary heart disease or other high-risk conditions.Population: AdultsDailyMed (U.S. National Library of Medicine)
• Adjunct to diet to reduce LDL-C in primary hyperlipidemia and in heterozygous familial hypercholesterolemia (age 10 years and older).Population: Adults and pediatric patients 10 years and olderDailyMed (U.S. National Library of Medicine)
• Homozygous familial hypercholesterolemia, primary dysbetalipoproteinemia and hypertriglyceridemia (adjunct therapy).Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (≥5%): upper respiratory tract infection, headache, abdominal pain, constipation and nausea.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Concomitant use of strong CYP3A4 inhibitors, cyclosporine, danazol or gemfibrozil.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Acute liver failure or decompensated cirrhosis.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity to simvastatin or any excipient.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Myopathy and rhabdomyolysis: risk increases with higher doses, age 65 or older, renal impairment, uncontrolled hypothyroidism and certain interacting drugs; discontinue if CK is markedly elevated or myopathy is suspected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Immune-mediated necrotizing myopathy has been reported; discontinue if suspected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hepatic dysfunction: consider liver enzyme testing before initiation and when clinically indicated; interrupt if serious hepatic injury occurs.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Strong CYP3A4 inhibitors, cyclosporine, danazol, gemfibrozilGreatly increased risk of myopathy/rhabdomyolysis; concomitant use contraindicated.DailyMed (U.S. National Library of Medicine)
• Verapamil, diltiazem, dronedaroneDo not exceed simvastatin 10 mg daily.DailyMed (U.S. National Library of Medicine)
• Amiodarone, amlodipine, ranolazineDo not exceed simvastatin 20 mg daily (this 40 mg tablet exceeds that limit).DailyMed (U.S. National Library of Medicine)

• Discontinue when pregnancy is recognized; may cause fetal harm based on mechanism of action. Alternatively, consider the ongoing therapeutic needs of the individual patient.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Breastfeeding is not recommended during treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Simvastatin: Inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis.