سعر ميناليب 20مجم 7 اقراص 2022

Simvastatin 20 mg film-coated tablets (Minalip; Alfacure Pharmaceuticals), pack of 7 tablets.

• To reduce the risk of total mortality by reducing CHD death, non-fatal myocardial infarction, stroke and need for revascularisation in adults with established CHD, other atherosclerotic vascular disease or diabetes, at high risk of CV events.Population: AdultsDailyMed (U.S. NLM)
• As an adjunct to diet to reduce LDL-C in adults with primary hyperlipidaemia.Population: AdultsDailyMed (U.S. NLM)
• As an adjunct to diet to reduce LDL-C in adults and paediatric patients aged 10 years and older with heterozygous familial hypercholesterolaemia (HeFH).Population: Adults and children aged 10 years and olderDailyMed (U.S. NLM)

• Commonly reported adverse reactions include upper respiratory infection, headache, abdominal pain, constipation and nausea.International label, same formulation · DailyMed (U.S. NLM)

• Concomitant use of strong CYP3A4 inhibitors.International label, same formulation · DailyMed (U.S. NLM)
• Concomitant use of cyclosporine, danazol or gemfibrozil.International label, same formulation · DailyMed (U.S. NLM)
• Acute liver failure or decompensated cirrhosis.International label, same formulation · DailyMed (U.S. NLM)

• Myopathy and rhabdomyolysis: risk is dose-related and increased with age 65 years or older, uncontrolled hypothyroidism, renal impairment, certain interacting drugs and higher doses (risk also higher in Chinese patients); discontinue if CK is markedly elevated or myopathy is suspected.International label, same formulation · DailyMed (U.S. NLM)
• Immune-mediated necrotising myopathy has been reported with statins.International label, same formulation · DailyMed (U.S. NLM)
• Hepatic dysfunction: increases in serum transaminases can occur; consider liver enzyme testing before starting and as clinically indicated; interrupt if serious hepatic injury occurs.International label, same formulation · DailyMed (U.S. NLM)

• Verapamil, diltiazem, dronedaroneDo not exceed simvastatin 10 mg daily with these drugs (increased myopathy risk).DailyMed (U.S. NLM)
• Amiodarone, amlodipine, ranolazineDo not exceed simvastatin 20 mg daily with these drugs.DailyMed (U.S. NLM)
• LomitapideReduce the simvastatin dose by 50%; do not exceed 20 mg daily (40 mg for patients previously on 80 mg chronically).DailyMed (U.S. NLM)

• Discontinue when pregnancy is recognised, or alternatively consider the ongoing therapeutic needs of the individual patient; simvastatin may cause fetal harm based on its mechanism of action, and treating hyperlipidaemia is not generally necessary during pregnancy.International label, same formulation · DailyMed (U.S. NLM)
• Breastfeeding is not recommended during treatment (statins may pass into human milk).International label, same formulation · DailyMed (U.S. NLM)

• Simvastatin: Inhibits HMG-CoA reductase, the rate-limiting enzyme of hepatic cholesterol synthesis, lowering LDL-C.