سعر ماروفاركس 240مجم 56 كبسولة 2022

Dimethyl fumarate 240 mg delayed-release capsules (56 per pack) by Hikma Pharma, Egypt, used in relapsing multiple sclerosis.

• Relapsing forms of multiple sclerosis (clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease) in adults.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions (incidence >=10% and >=2% more than placebo): flushing (40%), abdominal pain (18%), diarrhoea (14%) and nausea (12%); also vomiting, pruritus, rash, albumin in urine, erythema, dyspepsia, increased AST and lymphopenia.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to dimethyl fumarate or any excipient; reactions have included anaphylaxis and angioedema.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Anaphylaxis and angioedema can occur after the first dose or at any time; patients should stop the drug and seek immediate care.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Progressive multifocal leukoencephalopathy (PML) has occurred, including a fatal case with prolonged lymphopenia; withhold at the first sign or symptom suggestive of PML.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Serious herpes zoster and other serious opportunistic viral, fungal and bacterial infections have occurred.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Pregnancy registry, observational and pharmacovigilance data have not indicated an increased risk of major birth defects, miscarriage or other adverse maternal or fetal outcomes; in animals, adverse effects on offspring were seen at clinically relevant doses.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No data on the presence of dimethyl fumarate or monomethyl fumarate in human milk or on effects on the breastfed infant or milk production.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Dimethyl fumarate: Mechanism in MS unknown; dimethyl fumarate and its metabolite monomethyl fumarate activate the Nrf2 pathway involved in the cellular response to oxidative stress.