سعر ماركليروسيس 240مجم 56 كبسولة 2022

Dimethyl fumarate 240 mg delayed-release capsules, box of 56, by Marcyrl (Egypt), for relapsing multiple sclerosis.

• Relapsing forms of multiple sclerosis (clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease) in adults.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Flushing (40% in clinical trials); serious gastrointestinal events in 1% of treated patients in controlled trials (vomiting 0.3%, abdominal pain 0.3%).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to dimethyl fumarate or any excipient (reactions have included anaphylaxis and angioedema).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Anaphylaxis and angioedema can occur after the first dose or at any time; stop and seek immediate care.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Progressive multifocal leukoencephalopathy (PML) has occurred, including a fatal case in a patient with prolonged lymphopenia; withhold at the first sign or symptom suggestive of PML.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Serious herpes zoster and other serious opportunistic infections (viral, fungal, bacterial) have occurred.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• No data on presence of DMF or MMF in human milk or effects on the breastfed infant or milk production.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Dimethyl fumarate: Mechanism in MS unknown; DMF and its metabolite monomethyl fumarate activate the Nrf2 pathway involved in the cellular response to oxidative stress.