سعر ميبراديب 40مجم 14 كبسولة 2026

Esomeprazole 40 mg delayed-release capsules (proton pump inhibitor) by Debeiky, Egypt.

• Healing of erosive esophagitis (EE) due to acid-mediated GERDPopulation: Adults and pediatric patients 1 year and olderDailyMed (U.S. National Library of Medicine)
• Maintenance of healing of erosive esophagitisPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Treatment of symptomatic gastroesophageal reflux disease (GERD)Population: Adults and pediatric patients 1 year and olderDailyMed (U.S. National Library of Medicine)

• Most common adverse reactions in adults (>=1%): headache, diarrhea, nausea, flatulence, abdominal pain, constipation and dry mouth.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to substituted benzimidazoles or any component; co-administration with rilpivirine-containing products.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Symptomatic response does not exclude gastric malignancy. Acute tubulointerstitial nephritis, Clostridioides difficile-associated diarrhea, bone fractures (long-term, high-dose), severe cutaneous adverse reactions, cutaneous and systemic lupus erythematosus, vitamin B12 deficiency (long-term), hypomagnesemia and fundic gland polyps have been reported with PPIs.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Use the lowest dose and shortest duration appropriate to the condition. Avoid concomitant St John's wort or rifampin; PPIs may raise chromogranin A levels (stop at least 14 days before CgA testing) and may raise methotrexate levels.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• ClopidogrelEsomeprazole reduces exposure to the active metabolite of clopidogrel (CYP2C19 inhibition); consider an alternative anti-platelet therapy.DailyMed (U.S. National Library of Medicine)
• Rilpivirine; drugs dependent on gastric pH (e.g. ketoconazole, iron salts, erlotinib, mycophenolate mofetil)Rilpivirine is contraindicated; esomeprazole can reduce absorption of drugs that depend on gastric acidity.DailyMed (U.S. National Library of Medicine)
• MethotrexateConcomitant PPI use may elevate and prolong serum methotrexate levels, mainly at high methotrexate doses; consider temporary PPI withdrawal.DailyMed (U.S. National Library of Medicine)

• There are no adequate and well-controlled studies with esomeprazole in pregnant women. Esomeprazole is the S-isomer of omeprazole; available epidemiologic data with omeprazole fail to demonstrate an increased risk of major congenital malformations or other adverse pregnancy outcomes with first-trimester use.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Esomeprazole is likely present in human milk (omeprazole is present in low levels); weigh the benefits of breastfeeding against the mother's clinical need and potential adverse effects on the infant.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

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