سعر ايوبيتركسيد 500 مجم فيال 2024

Pemetrexed 500 mg powder for solution for intravenous infusion, single vial.

• Locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC): initial treatment with pembrolizumab and platinum chemotherapy, or with cisplatin; maintenance after 4 cycles of platinum first-line chemotherapy without progression; single agent after prior chemotherapy. Not indicated for squamous cell NSCLC.DailyMed (U.S. NLM)
• Malignant pleural mesothelioma (unresectable or not a surgical candidate), in combination with cisplatin.DailyMed (U.S. NLM)

• Most common adverse reactions (20% or more) as a single agent: fatigue, nausea and anorexia; with cisplatin: vomiting, neutropenia, anemia, stomatitis/pharyngitis, thrombocytopenia and constipation.International label, same formulation · DailyMed (U.S. NLM)

• History of severe hypersensitivity reaction to pemetrexed.International label, same formulation · DailyMed (U.S. NLM)

• Myelosuppression (reduced by folic acid and vitamin B12; do not give a new cycle unless ANC is at least 1500 cells/mm3 and platelets at least 100,000 cells/mm3), renal failure, bullous and exfoliative skin toxicity, interstitial pneumonitis, radiation recall and embryo-fetal toxicity.International label, same formulation · DailyMed (U.S. NLM)

• Ibuprofen (and other NSAIDs)Ibuprofen increases pemetrexed exposure; in patients with creatinine clearance 45-79 mL/min avoid ibuprofen from 2 days before through 2 days after pemetrexed.DailyMed (U.S. NLM)

• Can cause fetal harm; advise females of reproductive potential to use effective contraception during treatment and for 6 months after the last dose, and males with female partners for 3 months after the last dose.International label, same formulation · DailyMed (U.S. NLM)
• Advise women not to breastfeed during treatment and for 1 week after the last dose.International label, same formulation · DailyMed (U.S. NLM)

• Pemetrexed: Inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase, folate-dependent enzymes involved in purine and thymidine synthesis (US Alimta label).