سعر نازويل 150 مجم 3 كبسولة 2024

Nazowell 150 mg capsules, pack of 3 (Health Well, Egypt): fluconazole, typically used as a single-dose regimen for vaginal candidiasis among other labeled uses.

• Adults: cryptococcal meningitis; coccidioidomycosis; invasive candidiasis; mucosal candidiasis; prevention of candidal infections in immunocompromised patients; genital candidiasis (acute vaginal candidiasis / candidal balanitis) when appropriate (UK Diflucan SmPC).Population: Adultselectronic medicines compendium (emc), UK

• Common: headache, abdominal pain, diarrhoea, nausea, vomiting, rash, elevated liver enzymes.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Hypersensitivity to fluconazole or other azole antifungals; coadministration with terfenadine (at fluconazole ≥400 mg) or with drugs known to prolong QT and metabolized by CYP3A4 (e.g. cisapride, astemizole, pimozide, quinidine, erythromycin) per UK SmPC.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Hepatotoxicity: fluconazole has been associated with rare serious hepatic toxicity; monitor in patients with liver disease.International label, equivalent formulation · electronic medicines compendium (emc), UK
• QT prolongation and torsades de pointes reported; caution with proarrhythmic conditions and interacting drugs.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Embryo-fetal toxicity: high-dose/chronic fluconazole in pregnancy associated with congenital anomalies; avoid in pregnancy except in severe/life-threatening fungal infections when benefit outweighs risk (regulator labels).International label, equivalent formulation · electronic medicines compendium (emc), UK

• WarfarinMajorFluconazole may increase prothrombin time; monitor INR.electronic medicines compendium (emc), UK
• Oral hypoglycaemics (sulfonylureas)ModerateMay increase plasma concentrations and hypoglycaemia risk.electronic medicines compendium (emc), UK
• CYP3A4 / CYP2C9 substrates (e.g. midazolam, phenytoin, ciclosporin)MajorFluconazole is a moderate CYP2C9/CYP3A4 inhibitor; many clinically significant interactions.electronic medicines compendium (emc), UK

• UK SmPC: avoid in pregnancy except in severe/potentially life-threatening fungal infections when expected benefit outweighs risk; high-dose/long-course use linked to congenital anomalies.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Fluconazole is excreted in breast milk at concentrations similar to plasma; UK SmPC advises against breastfeeding after a single 150 mg or repeated/high doses (check current SmPC wording for the specific regimen).International label, equivalent formulation · electronic medicines compendium (emc), UK

• Fluconazole: Inhibits fungal cytochrome P-450-mediated 14-alpha-lanosterol demethylation, an essential step in ergosterol biosynthesis; more selective for fungal than mammalian cytochrome P-450 enzymes (UK Diflucan SmPC, section 5.1).