سعر نوكتوريليف 10مجم 10 اقراص 2022

Noctorelief 10 mg tablets (Pharopharma, Egypt): bambuterol 10 mg, an oral long-acting beta-2 agonist prodrug of terbutaline for asthma; pack of 10.

• Management of asthma, bronchospasm and/or reversible airways obstructione-lactancia (copy of eMC print of UK SmPC)

• Very common: tremor, headache, restlessness. Common: sleep disturbances, palpitations, muscle cramps. Uncommon: tachycardia, cardiac arrhythmias (atrial fibrillation, supraventricular tachycardia, extrasystoles), agitation. Not known: hypersensitivity reactions (angioedema, urticaria, exanthema, bronchospasm, hypotension, collapse), hypokalaemia, hyperglycaemia, dizziness, hyperactivity, myocardial ischaemia, paradoxical bronchospasm, nausea. Effects are dose-dependent and tolerance usually develops within 1-2 weeks.International label, same formulation · e-lactancia (copy of eMC print of UK SmPC)

• Hypersensitivity to bambuterol or any excipient.International label, same formulation · e-lactancia (copy of eMC print of UK SmPC)
• Not recommended in children because of limited clinical data.International label, same formulation · e-lactancia (copy of eMC print of UK SmPC)

• Caution in thyrotoxicosis.International label, same formulation · e-lactancia (copy of eMC print of UK SmPC)
• Cardiovascular effects, including rare myocardial ischaemia, may occur with beta-2 agonists; patients with severe heart disease should seek advice if chest pain or worsening heart disease occurs. Do not use in hypertrophic cardiomyopathy; beta-2 agonists may be arrhythmogenic.International label, same formulation · e-lactancia (copy of eMC print of UK SmPC)
• Additional blood glucose controls are recommended initially in diabetic patients (hyperglycaemic effect).International label, same formulation · e-lactancia (copy of eMC print of UK SmPC)

• Suxamethonium (succinylcholine) and other muscle relaxants metabolised by plasma cholinesteraseBambuterol partly inhibits plasma cholinesterase and can prolong suxamethonium muscle relaxation up to 2-fold (dose-dependent, reversible); may prolong apnoea.e-lactancia (copy of eMC print of UK SmPC)
• Halothane and other halogenated anaestheticsAvoid halothane during beta-2 agonist treatment (increased arrhythmia risk); use other halogenated anaesthetics cautiously.e-lactancia (copy of eMC print of UK SmPC)
• Beta-blockers (including eye drops), especially non-selectiveMay partly or totally inhibit the effect of beta-stimulants; not normally given together.e-lactancia (copy of eMC print of UK SmPC)

• Unknown whether bambuterol passes into breast milk; terbutaline is excreted in milk but no effect on breastfed infants is anticipated at therapeutic doses; weigh the benefit of breastfeeding against the benefit of therapy.International label, same formulation · e-lactancia (copy of eMC print of UK SmPC)

• Bambuterol: Active precursor (bis-dimethylcarbamate prodrug) of the selective beta-2 adrenergic agonist terbutaline; bambuterol also partly and reversibly inhibits plasma cholinesterase.