سعر اوستيورين 50 مجم 30 كبسولة 2022

Diacerein 50 mg hard capsules, pack of 30, marketed in Egypt by Medizen Pharmaceutical Industries; slow-acting symptomatic treatment of osteoarthritis.

• Symptomatic treatment with delayed effect of osteoarthritis of the hip and knee (adults over 15 years).Population: Adults over 15 yearsBase de Données Publique des Médicaments (ANSM)

• Very common: diarrhoea, abdominal pain. Common: frequent stools, flatulence, pruritus, rash, eczema. Rare: raised liver enzymes. Also: urine discoloration, colonic melanosis; post-marketing acute liver injury.International label, same formulation · Base de Données Publique des Médicaments (ANSM)

• Inflammatory bowel disease (ulcerative colitis, Crohn disease), intestinal obstruction or sub-obstruction, abdominal pain of unknown cause, hypersensitivity to rhein or excipients, current or past liver disease.International label, same formulation · Base de Données Publique des Médicaments (ANSM)

• Diarrhoea is frequent and may cause dehydration and hypokalaemia; stop treatment if diarrhoea occurs. Avoid laxatives.International label, same formulation · Base de Données Publique des Médicaments (ANSM)
• Hepatotoxicity: raised liver enzymes and acute liver injury reported; screen for liver disease before starting, monitor for signs of liver injury, limit alcohol and stop if enzymes rise.International label, same formulation · Base de Données Publique des Médicaments (ANSM)
• Contains lactose; not for patients with hereditary galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption (ART 50 mg formulation).International label, same formulation · Base de Données Publique des Médicaments (ANSM)

• Gastrointestinal antacids/adsorbents (aluminium, calcium, magnesium salts, oxides, hydroxides)Reduced absorption of diacerein; separate administration by more than 2 hours.Base de Données Publique des Médicaments (ANSM)
• Diuretics (loop, thiazide) and cardiac glycosides (digoxin, digitoxin)Diarrhoea-induced hypokalaemia increases the risk of arrhythmia; use with particular caution.Base de Données Publique des Médicaments (ANSM)

• Not recommended during pregnancy: insufficient clinical data; animal study showed delayed fetal ossification due to maternal toxicity at high doses.International label, same formulation · Base de Données Publique des Médicaments (ANSM)
• Not recommended during breastfeeding; small amounts of anthraquinone derivatives pass into breast milk.International label, same formulation · Base de Données Publique des Médicaments (ANSM)

• Diacerein: Anthraquinone derivative fully deacetylated to rhein; in vitro inhibits interleukin-1 production, macrophage phagocytosis/migration and collagenolytic activity; slow onset (about day 30, significant around day 45).