سعر باروكسيديب سي ار 25 مجم 2024

Paroxedep CR 25 mg: paroxetine 25 mg controlled-release film-coated tablet, 30 tablets per pack (Egypt; Apex Pharma).

• Major depressive disorder (MDD)Population: AdultsDailyMed (U.S. National Library of Medicine)
• Panic disorderPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Social anxiety disorderPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most common: nausea, somnolence, insomnia, dizziness, dry mouth, sweating, tremor, asthenia, constipation, diarrhoea, decreased appetite, abnormal ejaculation, impotence and decreased libido.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Use with, or within 14 days of stopping, MAOIs (including linezolid and intravenous methylene blue) because of serotonin syndrome risk.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Concomitant drugs that prolong the QTc interval and are CYP2D6 substrates (e.g. thioridazine, pimozide).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Known hypersensitivity to paroxetine or any excipient (reactions have included anaphylaxis, angioedema and Stevens-Johnson syndrome).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: antidepressants increased the risk of suicidal thoughts and behaviours in children and young adults; monitor all patients for clinical worsening and suicidality.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Serotonin syndrome, increased bleeding risk (monitor INR with warfarin), seizures, angle-closure glaucoma, hyponatremia, sexual dysfunction and activation of mania; screen for bipolar disorder before starting.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Discontinuation syndrome: taper the dose gradually.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Monoamine oxidase inhibitors (incl. linezolid, IV methylene blue)Contraindicated: risk of serotonin syndrome; separate by at least 14 days.DailyMed (U.S. National Library of Medicine)
• Thioridazine, pimozide and other QTc-prolonging CYP2D6 substratesContraindicated: paroxetine inhibits CYP2D6, raising exposure and QT risk.DailyMed (U.S. National Library of Medicine)
• TamoxifenParoxetine CYP2D6 inhibition may reduce formation of the active tamoxifen metabolite and its efficacy.DailyMed (U.S. National Library of Medicine)

• For women planning pregnancy or in the first trimester, start paroxetine only after considering other treatment options; first-trimester exposure has been associated with cardiovascular malformations in some studies.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Paroxetine is present in human milk; agitation, irritability, poor feeding and poor weight gain reported in exposed infants; weigh benefits and monitor the infant.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Paroxetine: Selectively inhibits neuronal reuptake of serotonin (5-HT), increasing synaptic serotonin activity.