سعر Aprimertaz 30 mg 30 film-coated tablets 2022

Mirtazapine 30 mg film-coated tablets, pack of 30 (Egypt); tetracyclic antidepressant.

• Treatment of major depressive disorder (MDD) in adultsPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most common (>=5% and twice placebo) in 6-week US MDD trials: somnolence 54%, increased appetite 17%, weight gain 12%, dizziness 7%; dry mouth was reported in 25% (placebo 15%).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Use with, or within 14 days of stopping, an MAOI (including linezolid or intravenous methylene blue) because of the risk of serotonin syndrome.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Known hypersensitivity to mirtazapine or to any excipient.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: antidepressants increased the risk of suicidal thoughts and behaviours in pediatric and young adult patients; closely monitor all patients for clinical worsening and emergence of suicidal thoughts.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Agranulocytosis/severe neutropenia has occurred; stop treatment if sore throat, fever, stomatitis or other signs of infection occur with a low white blood cell count.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Serotonin syndrome, particularly with other serotonergic drugs (triptans, tricyclics, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, St John's wort).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• MAOIs (e.g. selegiline, tranylcypromine, phenelzine, linezolid, IV methylene blue)Contraindicated: increased risk of serotonin syndrome; allow at least 14 days between stopping one and starting the other.DailyMed (U.S. National Library of Medicine)
• Other serotonergic drugs (SSRIs, SNRIs, triptans, tricyclics, fentanyl, lithium, tramadol, St John's wort, tryptophan, buspirone, amphetamines)Increased risk of serotonin syndrome; monitor, particularly at initiation and dose increases.DailyMed (U.S. National Library of Medicine)
• Strong CYP3A inducers (e.g. carbamazepine, phenytoin, rifampin)Decrease mirtazapine plasma concentrations; a mirtazapine dose increase may be needed (and decrease when the inducer is stopped).DailyMed (U.S. National Library of Medicine)

• Published observational studies and postmarketing reports have not reliably identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes; untreated depression in pregnancy carries risks. In rats, increased post-implantation loss and pup deaths occurred at 20 times the maximum human dose.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Present in human milk at low levels (relative infant dose 0.6-2.8%); no adverse effects reported in most breastfed infants; no data on milk production. Weigh the benefits of breastfeeding against the mother's need for treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Mirtazapine: Mechanism in major depressive disorder unclear; efficacy could be mediated through antagonism of central presynaptic alpha2-adrenergic inhibitory autoreceptors and heteroreceptors, enhancing central noradrenergic and serotonergic activity.