سعر بنتازا 1 جم/100 مل 7 حقنة شرجية 2026

Mesalazine 1 g/100 ml rectal suspension (Pentasa enema, Ferring), an aminosalicylate intestinal anti-inflammatory; box of 7 enemas.

• Ulcerative colitis affecting the distal colon and rectumPopulation: Adultselectronic medicines compendium (emc)

• Most frequent adverse reactions in clinical trials: diarrhoea, nausea, abdominal pain, headache, vomiting and rash; hypersensitivity reactions and drug fever may occur; altered blood counts, myo-/pericarditis, pancreatitis, hepatic and renal reactions are rare or very rare.International label, same formulation · electronic medicines compendium (emc)

• Hypersensitivity to mesalazine, salicylates or any of the excipients.International label, same formulation · electronic medicines compendium (emc)
• Severe liver and/or renal impairment.International label, same formulation · electronic medicines compendium (emc)

• Severe cutaneous adverse reactions (DRESS, SJS, TEN) have been reported; stop immediately at the first signs of severe skin reaction or acute intolerance (cramps, abdominal pain, fever, severe headache). Use caution in patients allergic to sulfasalazine.International label, same formulation · electronic medicines compendium (emc)
• Not recommended in impaired renal function or haemorrhagic diathesis; monitor renal function (serum creatinine, urine dipstick) especially early in treatment and discontinue if renal function deteriorates. Concurrent nephrotoxic agents (NSAIDs, azathioprine) may increase renal risk. Ensure adequate fluid intake (nephrolithiasis reported).International label, same formulation · electronic medicines compendium (emc)
• Caution in hepatic impairment (assess ALT/AST) and pulmonary disease, especially asthma. Rare myocarditis/pericarditis and very rare serious blood dyscrasias; blood counts recommended before and during treatment. Idiopathic intracranial hypertension has been reported.International label, same formulation · electronic medicines compendium (emc)

• Azathioprine, 6-mercaptopurine, thioguanineHigher frequency of myelosuppression with combination; monitor white cells and adjust thiopurine dosage.electronic medicines compendium (emc)
• WarfarinWeak evidence that mesalazine may decrease the anticoagulant effect of warfarin.electronic medicines compendium (emc)

• Should not be used in pregnancy unless the potential benefit outweighs the possible hazards in the physician's opinion; mesalazine crosses the placenta. Limited human data show no increase in congenital malformations; blood disorders have been reported in newborns of treated mothers.International label, same formulation · electronic medicines compendium (emc)
• Excreted in breast milk (acetyl-mesalazine at similar or higher levels than in maternal blood); diarrhoea in the infant cannot be excluded; stop breastfeeding if the infant develops diarrhoea.International label, same formulation · electronic medicines compendium (emc)

• Mesalazine: Acts mainly locally on the inflamed intestinal mucosa; therapeutic activity depends on local contact with the diseased area (UK SmPC).