سعر مارسالاز 500مجم 30 قرص 2024

Mesalazine 500 mg enteric-coated (gastro-resistant) tablets, 30 per pack, by Marcyrl Pharmaceutical Industries, Egypt, for ulcerative colitis.

• Treatment of acute episodes and maintenance of remission of ulcerative colitis.Population: Adults and children 6 years and olderelectronic medicines compendium (emc)

• Reported adverse reactions include headache, dizziness, abdominal pain, diarrhoea, dyspepsia, flatulence, nausea, vomiting, rash, pruritus, photosensitivity, arthralgia, asthenia and fatigue; rarer serious reactions include blood dyscrasias, myocarditis, pericarditis, pancreatitis, hepatitis, lung reactions, interstitial nephritis, renal insufficiency and SCARs.International label, same formulation · electronic medicines compendium (emc)

• Hypersensitivity to mesalazine, salicylates or any excipient.International label, same formulation · electronic medicines compendium (emc)
• Severe impairment of hepatic or renal function.International label, same formulation · electronic medicines compendium (emc)

• Nephrolithiasis has been reported; ensure adequate fluid intake.International label, same formulation · electronic medicines compendium (emc)
• Serious blood dyscrasias have been reported very rarely; investigate unexplained bleeding, bruising, purpura, anaemia, fever or sore throat and stop if dyscrasia is suspected.International label, same formulation · electronic medicines compendium (emc)
• Myocarditis and pericarditis have been reported rarely; stop immediately if they occur.International label, same formulation · electronic medicines compendium (emc)

• Azathioprine, 6-mercaptopurine, thioguanineA possible increase in their myelosuppressive effects should be taken into account.electronic medicines compendium (emc)
• WarfarinWeak evidence that mesalazine might decrease the anticoagulant effect of warfarin.electronic medicines compendium (emc)

• Data from a limited number of exposed pregnancies show no adverse effect on pregnancy or the newborn, and animal studies show no harm; one case of neonatal renal failure after long-term high-dose (2-4 g) use was reported; use only if the potential benefit outweighs the possible risk.International label, same formulation · electronic medicines compendium (emc)
• Mesalazine and its metabolite are excreted in breast milk; hypersensitivity reactions such as diarrhoea in the infant cannot be excluded; use only if benefit outweighs risk and stop breastfeeding if the infant develops diarrhoea.International label, same formulation · electronic medicines compendium (emc)

• Mesalazine: Anti-inflammatory mechanism unknown; in vitro data suggest lipoxygenase inhibition, effects on mucosal prostaglandins and scavenging of reactive oxygen species; acts mainly locally on the gut mucosa.