سعر بالسينوفا 750 مجم 30 كبسولة 2022

Balsinova (balsalazide 750 mg) capsules by Alfacure Pharmaceuticals, an aminosalicylate prodrug of mesalazine used for ulcerative colitis; pack of 30 capsules (3 strips).

• Treatment of mildly to moderately active ulcerative colitisPopulation: Patients 5 years of age and olderDailyMed (U.S. National Library of Medicine)

• Adults (6.75 g/day, controlled trials): headache 8%, abdominal pain 6%, diarrhoea 5%, nausea 5%, vomiting 4%, respiratory infection 4%, arthralgia 4%.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Children 5-17 years: headache 15%, upper abdominal pain 13%, abdominal pain 12%, vomiting 10%, diarrhoea 9%.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Post-marketing (balsalazide or mesalazine products): myocarditis, pericarditis, vasculitis, pneumonitis, interstitial nephritis, pancreatitis, hepatotoxicity, alopecia, SJS/TEN/DRESS/AGEP; urine discoloration on contact with hypochlorite bleach.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known or suspected hypersensitivity to salicylates, aminosalicylates, any capsule component or balsalazide metabolites.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Renal impairment (minimal change disease, interstitial nephritis, renal failure) reported with mesalazine-releasing products.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Mesalazine-induced acute intolerance syndrome (cramping, abdominal pain, bloody diarrhoea, sometimes fever, headache, rash) may mimic a colitis flare; discontinue promptly if suspected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity reactions, including myocarditis, pericarditis, nephritis, hepatitis, pneumonitis and blood abnormalities; patients sensitive to sulfasalazine may react similarly.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Nephrotoxic agents, including NSAIDsMay increase the risk of renal reactions; monitor renal function.DailyMed (U.S. National Library of Medicine)
• Azathioprine, 6-mercaptopurine and other myelotoxic drugsIncreased risk of blood disorders and bone marrow failure; monitor blood and platelet counts.DailyMed (U.S. National Library of Medicine)

• Published data on mesalazine (the active moiety) in pregnancy have not reliably shown an association with major birth defects, miscarriage or adverse maternal/fetal outcomes; no adverse developmental effects in rat and rabbit studies. Active ulcerative colitis itself is associated with adverse pregnancy outcomes.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Mesalazine and N-acetyl-5-ASA pass into milk in small amounts (RID 0.1% or less); diarrhoea has been reported in breastfed infants - monitor the infant; weigh benefits of breastfeeding against maternal need.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Balsalazide: Delivered intact to the colon, where bacterial azoreduction releases mesalazine (5-ASA), which appears to act locally on colonic mucosa, possibly by blocking production of arachidonic acid metabolites (US labeling).