سعر روفاك 3 مليون وحدة دولية 10 اقراص 2025

Spiramycin 3 million IU film-coated tablets (Rovac, Delta Pharma, Egypt), a macrolide antibiotic; box of 10 tablets.

• Documented group A beta-haemolytic streptococcal tonsillitis/pharyngitis, as an alternative to beta-lactamsPopulation: AdultsBase de données publique des médicaments (ANSM)
• Acute sinusitis (when a beta-lactam cannot be used); superinfection of acute bronchitis; exacerbations of chronic bronchitisPopulation: AdultsBase de données publique des médicaments (ANSM)
• Community-acquired pneumonia in patients without risk factors or severity signs and without features suggesting pneumococcal aetiology; suspected atypical pneumoniaPopulation: AdultsBase de données publique des médicaments (ANSM)

• Very common: occasional transient paraesthesia. Common: abdominal pain, nausea, vomiting, gastralgia, diarrhoea, pseudomembranous colitis, rash, transient dysgeusia. Very rare: liver test abnormalities. Frequency not known: QT prolongation, ventricular arrhythmia/tachycardia, torsades de pointes, vasculitis (including Henoch-Schönlein purpura), anaphylactic shock, urticaria, pruritus, angioedema, SJS/TEN/AGEP, cholestatic or mixed hepatitis, leucopenia, neutropenia, haemolytic anaemia.International label, same formulation · Base de données publique des médicaments (ANSM)

• Hypersensitivity to spiramycin or any excipient.International label, same formulation · Base de données publique des médicaments (ANSM)
• Previous Stevens-Johnson syndrome, toxic epidermal necrolysis or AGEP with spiramycin contraindicates any new administration of spiramycin alone or in combination.International label, same formulation · Base de données publique des médicaments (ANSM)

• Severe cutaneous reactions (Stevens-Johnson syndrome, Lyell syndrome, acute generalised exanthematous pustulosis) have been reported; inform patients of the signs and stop treatment if they occur.International label, same formulation · Base de données publique des médicaments (ANSM)
• Very rare haemolytic anaemia has been reported in G6PD deficiency; use in these patients is not recommended.International label, same formulation · Base de données publique des médicaments (ANSM)
• QT prolongation has been reported with macrolides including spiramycin; use with caution in patients with uncorrected hypokalaemia/hypomagnesaemia, congenital long QT, cardiac disease (heart failure, myocardial infarction, bradycardia) or concomitant QT-prolonging drugs; elderly people, neonates and women may be more sensitive.International label, same formulation · Base de données publique des médicaments (ANSM)

• Torsadogenic drugs (class Ia and III antiarrhythmics, sultopride, cisapride, IV erythromycin, levofloxacin, moxifloxacin, mizolastine and others)Increased risk of ventricular arrhythmias, notably torsades de pointes (precaution for use).Base de données publique des médicaments (ANSM)
• Levodopa (with carbidopa)Inhibition of carbidopa absorption with reduced levodopa plasma levels; clinical monitoring and possible levodopa dose adjustment.Base de données publique des médicaments (ANSM)
• Hydroxychloroquine or chloroquineUse with caution because of possible serious cardiovascular effects (QT prolongation, arrhythmias, torsades de pointes) and increased cardiovascular mortality risk.Base de données publique des médicaments (ANSM)

• Spiramycin may be considered during pregnancy if needed; wide use in pregnancy has not shown malformative or fetotoxic effects to date.International label, same formulation · Base de données publique des médicaments (ANSM)
• Spiramycin passes into breast milk in non-negligible amounts and digestive disorders have been described in newborns; breastfeeding is not advised during treatment.International label, same formulation · Base de données publique des médicaments (ANSM)

• Spiramycin: Macrolide that binds the 50S ribosomal subunit and inhibits bacterial protein synthesis; also active in vitro and in vivo against Toxoplasma gondii.