سعر روفيابريجا 150مجم 20 كبسول 2022

Roviaprega 150 mg capsules (pack of 20) contain pregabalin, a gabapentinoid (alpha2-delta calcium-channel ligand) used for neuropathic pain, adjunctive treatment of partial-onset seizures and fibromyalgia; listed in Egypt under Marcyrl Co. / Bahrain Pharma.

• Management of neuropathic pain associated with diabetic peripheral neuropathyPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Management of postherpetic neuralgiaPopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Adjunctive therapy for partial-onset seizuresPopulation: Patients 1 month of age and olderDailyMed (U.S. National Library of Medicine)

• Most common in controlled adult trials: dizziness, somnolence, dry mouth, oedema, blurred vision, weight gain and abnormal thinking (mainly difficulty with concentration/attention).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to pregabalin or any of its components (angioedema and hypersensitivity reactions have occurred).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Angioedema (face, mouth, throat swelling; may be life-threatening) and hypersensitivity reactions: discontinue immediately; caution in patients with previous angioedema or on other angioedema-associated drugs such as ACE inhibitors.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Antiepileptic drugs including pregabalin increase the risk of suicidal thoughts or behaviour; monitor for depression, mood changes and suicidality.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Serious, life-threatening or fatal respiratory depression may occur when combined with CNS depressants including opioids, or with underlying respiratory impairment; consider a low starting dose and monitor.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Opioids and other CNS depressants (e.g. oxycodone, lorazepam, alcohol)Additive impairment of cognitive and gross motor function; risk of respiratory depression with CNS depressants.DailyMed (U.S. National Library of Medicine)
• ACE inhibitorsPossible increased risk of angioedema when used together.DailyMed (U.S. National Library of Medicine)

• Observational studies suggest a possible small increase in overall major birth defects without a consistent pattern; data on miscarriage and other outcomes are insufficient. A pregnancy exposure registry exists.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Small amounts pass into breast milk (milk levels about 76% of maternal plasma; estimated infant dose about 7% of the maternal mg/kg dose); effects on the breastfed infant were not studied.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Pregabalin: Binds with high affinity to the alpha2-delta auxiliary subunit of voltage-gated calcium channels in CNS tissue; does not bind GABA-A/GABA-B or benzodiazepine receptors (US label).