سعر سالازوسين 500 مجم 10 قرص مغلف معوي 2022

Sulfasalazine 500 mg enteric film-coated tablet (Delta Pharma > Science Pharma-Egypt); an aminosalicylate-sulfonamide used for ulcerative colitis, Crohn's disease and rheumatoid arthritis.

• Induction and maintenance of remission of ulcerative colitis; treatment of active Crohn's disease.Population: Adults and children aged 2 years and olderelectronic medicines compendium (emc), UK
• Rheumatoid arthritis that has failed to respond to NSAIDs.Population: Adultselectronic medicines compendium (emc), UK

• Most common: nausea, headache, rash, loss of appetite and raised temperature; about 75% of ADRs occur within 3 months.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Common: leukopenia, insomnia, dizziness, taste disorders, tinnitus, cough; not known: agranulocytosis, aplastic or haemolytic anaemia, folate deficiency, aseptic meningitis.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Infants under 2 years of age.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Hypersensitivity to sulfasalazine, its metabolites, sulfonamides, salicylates or any excipient.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Porphyria.International label, equivalent formulation · electronic medicines compendium (emc), UK

• Serious infections associated with myelosuppression (including sepsis and pneumonia) have been reported; patients should report sore throat, fever, malaise, pallor, purpura or jaundice immediately (possible myelosuppression, haemolysis or hepatotoxicity).International label, equivalent formulation · electronic medicines compendium (emc), UK
• Not to be given to patients with impaired hepatic function or blood dyscrasias unless benefit outweighs risk; caution in severe allergy or bronchial asthma; baseline renal impairment requires benefit-risk assessment.International label, equivalent formulation · electronic medicines compendium (emc), UK
• Severe hypersensitivity reactions (DRESS, hepatitis, nephritis, myocarditis, pneumonitis) and serious skin reactions (SJS, TEN, exfoliative dermatitis), mostly in the first month; stop at the first sign of rash, mucosal lesions or hypersensitivity.International label, equivalent formulation · electronic medicines compendium (emc), UK

• DigoxinReduced absorption of digoxin with non-therapeutic serum levels has been reported.electronic medicines compendium (emc), UK
• Oral hypoglycaemic agentsHypoglycaemia has occurred with sulfonamides; monitor patients on hypoglycaemic agents closely.electronic medicines compendium (emc), UK
• Azathioprine / 6-mercaptopurineThiopurine methyltransferase inhibition: bone marrow suppression and leucopenia reported with concomitant use.electronic medicines compendium (emc), UK

• Use in pregnancy only if clearly needed: sulfasalazine inhibits folic acid absorption and metabolism; neural tube defects have been reported (causal role not established); animal studies showed no fetal harm.International label, equivalent formulation · electronic medicines compendium (emc), UK
• UK SmPC: avoid breastfeeding; sulfasalazine and sulfapyridine are found in low levels in milk, and bloody stools or diarrhoea have been reported in breastfed infants.International label, equivalent formulation · electronic medicines compendium (emc), UK

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