سعر سيبانوين جل لحب الشباب 15 جرام 2024

Sebanoin acne gel 15 g (Melano Pharma, Egypt): topical gel containing erythromycin 2% and isotretinoin 0.05% (macrolide antibiotic plus topical retinoid) for acne.

• Topical treatment of mild to moderate acne vulgaris in adults and children over 12 years.Population: Adults and children over 12 yearsHealth Products Regulatory Authority (HPRA)

• Very common: rash, dryness, erythema, scaling, burning, pruritus, skin irritation, pain. Common: application-site reactions including eczema and exfoliative dermatitis. Rare (post-marketing): allergic reaction, abdominal discomfort or pain, diarrhoea, photosensitivity, skin discolouration or hyper/hypopigmentation, urticaria, facial oedema.International label, same formulation · Health Products Regulatory Authority (HPRA)

• Hypersensitivity to erythromycin, isotretinoin or any excipient; pregnancy and women planning a pregnancy.International label, same formulation · Health Products Regulatory Authority (HPRA)

• Avoid the mouth, eyes, lips, mucous membranes and broken skin; take care on sensitive areas and with coexisting rosacea or perioral dermatitis; cumulative irritation may occur with other topical acne therapies or drying cosmetics. Reduce frequency or interrupt if irritation occurs.International label, same formulation · Health Products Regulatory Authority (HPRA)
• Topical erythromycin may induce resistance in Cutibacterium (Propionibacterium) acnes and other bacteria, with possible cross-resistance to other macrolides and clindamycin; stop if clinical resistance develops. Consider pseudomembranous colitis if diarrhoea occurs.International label, same formulation · Health Products Regulatory Authority (HPRA)
• Isotretinoin increases sensitivity to sunlight: avoid sunlamps and prolonged sun exposure, use broad-spectrum sunscreen and protective clothing; use with caution with a personal or family history of skin cancer. Contains butylated hydroxytoluene, which may cause local skin reactions.International label, same formulation · Health Products Regulatory Authority (HPRA)

• Clindamycin-containing productsShould not be combined because of possible antagonism to the clindamycin component.Health Products Regulatory Authority (HPRA)
• Oxidising agents (e.g. benzoyl peroxide)May reduce the efficacy of topical isotretinoin; if combination is needed, apply at different times of day.Health Products Regulatory Authority (HPRA)

• Contraindicated in pregnancy and in women planning a pregnancy; discontinue if pregnancy occurs. Oral retinoids are associated with congenital abnormalities; topical use generally gives low systemic exposure, but a damaged skin barrier or excessive use may increase it.International label, same formulation · Health Products Regulatory Authority (HPRA)
• Not studied in breastfeeding; excretion of topical erythromycin or isotretinoin into milk is unknown and a risk to the infant cannot be excluded. Decide whether to stop breastfeeding or the product.International label, same formulation · Health Products Regulatory Authority (HPRA)

• Erythromycin:
• Isotretinoin: 13-cis isomer of retinoic acid; when applied topically it is thought to act like tretinoin, normalising follicular keratinisation, eliminating comedones and suppressing micro-comedone formation, with local anti-inflammatory action (inhibition of LTB4-induced leukocyte migration).