سعر سينميت 25/250مجم 20 قرص 2024

Carbidopa 25 mg + levodopa 250 mg immediate-release tablets for Parkinson's disease (MSD brand), Egyptian market.

• Treatment of Parkinson's disease, post-encephalitic parkinsonism, and symptomatic parkinsonism following carbon monoxide or manganese intoxication.Population: Adults (use below 18 years not recommended)DailyMed (U.S. National Library of Medicine)

• Most common: dyskinesias (choreiform, dystonic and other involuntary movements) and nausea. Others include orthostatic hypotension, cardiac irregularities, dark saliva, GI bleeding, haematologic reactions (agranulocytosis, anaemia, thrombocytopenia), hallucinations, confusion and somnolence.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Nonselective MAO inhibitors are contraindicated (stop at least 2 weeks before starting); selective MAO-B inhibitors such as selegiline may be used at the recommended dose. Also contraindicated in known hypersensitivity to any component and in narrow-angle glaucoma.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Stop plain levodopa at least 12 hours before starting. Dyskinesias may occur at lower doses and sooner than with levodopa alone. Observe for depression with suicidal tendencies. Use cautiously in severe cardiovascular or pulmonary disease, bronchial asthma, renal, hepatic or endocrine disease, history of myocardial infarction with residual arrhythmias, and history of peptic ulcer (risk of upper GI haemorrhage).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Vitamin B6 deficiency and seizures: treatment may reduce vitamin B6 levels (higher risk with higher doses); refractory seizures resolving only with vitamin B6 have been reported. Evaluate vitamin B6 before and periodically during treatment and supplement as needed.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Falling asleep during activities of daily living and somnolence (including while driving) may occur without warning; NMS-like hyperpyrexia and confusion may follow abrupt dose reduction or withdrawal; hallucinations/psychotic-like behaviour and impulse-control/compulsive behaviours have been reported with dopaminergic drugs.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Antihypertensive drugsSymptomatic postural hypotension may occur; antihypertensive dose adjustment may be required.DailyMed (U.S. National Library of Medicine)
• Dopamine D2 antagonists (phenothiazines, butyrophenones, risperidone), isoniazid, phenytoin, papaverineMay reduce the therapeutic effect of levodopa; observe for loss of response.DailyMed (U.S. National Library of Medicine)
• Iron salts (including iron-containing multivitamins)May chelate levodopa/carbidopa and reduce bioavailability; coadminister with caution.DailyMed (U.S. National Library of Medicine)

• No adequate well-controlled studies in pregnant women; carbidopa/levodopa caused visceral and skeletal malformations in rabbits; levodopa crosses the human placenta. Weigh anticipated benefits against possible hazards to mother and child.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Levodopa has been detected in human milk; use caution in nursing women.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Carbidopa: Inhibits peripheral decarboxylation of levodopa and does not cross the blood-brain barrier, increasing levodopa available to the brain.
• Levodopa: Crosses the blood-brain barrier and is converted to dopamine in the brain, relieving symptoms of Parkinson's disease.