سعر سوني سمابيكس 25/250مجم 30 قرص 2025

Carbidopa 25 mg + levodopa 250 mg film-coated tablets, pack of 30 (3 strips); Apex Pharma, Egypt.

• Treatment of Parkinson's disease, post-encephalitic parkinsonism, and symptomatic parkinsonism that may follow carbon monoxide or manganese intoxication.Population: AdultsDailyMed (U.S. NLM)

• Most common: dyskinesias (choreiform, dystonic and other involuntary movements) and nausea; others include orthostatic hypotension, confusion, hallucinations, somnolence, dark urine/saliva/sweat.International label, equivalent formulation · DailyMed (U.S. NLM)

• Nonselective MAO inhibitors (discontinue at least two weeks before starting); selective MAO-B inhibitors at recommended doses may be used.International label, equivalent formulation · DailyMed (U.S. NLM)
• Known hypersensitivity to any component, and narrow-angle glaucoma.International label, equivalent formulation · DailyMed (U.S. NLM)

• Dyskinesias may occur at lower doses and sooner than with levodopa alone; observe patients for depression with suicidal tendencies; use cautiously in severe cardiovascular or pulmonary disease, bronchial asthma, and renal, hepatic or endocrine disease.International label, equivalent formulation · DailyMed (U.S. NLM)
• Sudden sleep onset during daily activities (including driving) and somnolence have been reported; advise caution when driving or operating machinery.International label, equivalent formulation · DailyMed (U.S. NLM)
• A neuroleptic malignant syndrome-like complex (hyperpyrexia and confusion) may follow abrupt dose reduction or withdrawal; hallucinations, psychotic-like behaviour and impulse-control disorders may occur.International label, equivalent formulation · DailyMed (U.S. NLM)

• Antihypertensive drugsSymptomatic postural hypotension has occurred; antihypertensive dose adjustment may be required.DailyMed (U.S. NLM)
• Dopamine D2 antagonists (phenothiazines, butyrophenones, risperidone), isoniazid, phenytoin, papaverineMay reduce the therapeutic effect of levodopa; observe for loss of response.DailyMed (U.S. NLM)
• Iron saltsChelation may reduce bioavailability of carbidopa and levodopa; co-administer with caution.DailyMed (U.S. NLM)

• No adequate studies in pregnant women; levodopa crosses the placenta; visceral and skeletal malformations occurred in rabbits; use only if anticipated benefit outweighs possible hazards.International label, equivalent formulation · DailyMed (U.S. NLM)
• Levodopa has been detected in human milk; use with caution in nursing women.International label, equivalent formulation · DailyMed (U.S. NLM)

• Carbidopa: Inhibits peripheral decarboxylation of levodopa and does not cross the blood-brain barrier, so more levodopa reaches the brain.
• Levodopa: Metabolic precursor of dopamine that crosses the blood-brain barrier and is decarboxylated to dopamine in the brain.