سعر سينوبريل 5مجم 20 قرص 2024

Sinopril 5 mg tablets (lisinopril), 20 tablets (2 strips of 10), by Global Napi Pharmaceuticals (Egypt); an angiotensin-converting enzyme (ACE) inhibitor.

• Hypertension (adults and children >=6 years)Population: Adults; pediatric >=6 yearsDailyMed (U.S. National Library of Medicine)
• Adjunct therapy for heart failurePopulation: AdultsDailyMed (U.S. National Library of Medicine)
• Reduction of mortality in acute myocardial infarction (haemodynamically stable, within 24 h)Population: AdultsDailyMed (U.S. National Library of Medicine)

• Common (>2% above placebo): hypertension - headache, dizziness, cough; heart failure - hypotension, chest pain; acute MI - hypotension.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• History of angioedema or hypersensitivity related to previous ACE inhibitor treatment; hereditary or idiopathic angioedema.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Combination with a neprilysin inhibitor (e.g. sacubitril); do not give within 36 hours of switching to or from sacubitril/valsartan.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Co-administration with aliskiren in patients with diabetes.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Angioedema (head/neck and intestinal), including fatal cases, can occur at any time; discontinue promptly. Risk may be higher with mTOR inhibitors or neprilysin inhibitors and in black patients.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hyperkalaemia: risk factors include renal insufficiency, diabetes and potassium-sparing diuretics, potassium supplements or potassium-containing salt substitutes; monitor serum potassium periodically.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Neprilysin inhibitors (sacubitril)Contraindicated; increased angioedema risk; 36-hour washout.DailyMed (U.S. National Library of Medicine)
• AliskirenDo not co-administer in patients with diabetes.DailyMed (U.S. National Library of Medicine)
• Potassium-sparing diuretics, potassium supplements, potassium-containing salt substitutesIncreased risk of hyperkalaemia.DailyMed (U.S. National Library of Medicine)

• Boxed warning (fetal toxicity): lisinopril can cause fetal harm; drugs acting on the renin-angiotensin system during the second and third trimesters reduce fetal renal function and increase fetal and neonatal morbidity and death. Discontinue as soon as pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• No human milk data; lisinopril is present in rat milk. Because of the potential for severe adverse reactions in the breastfed infant, advise women not to breastfeed during treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Lisinopril: Inhibits angiotensin-converting enzyme, reducing angiotensin II formation and aldosterone secretion (suppression of the renin-angiotensin-aldosterone system).