سعر سينوبريل كو 12.5/20مجم 30 قرص 2024

Sinopril-co tablets (lisinopril 20 mg + hydrochlorothiazide 12.5 mg), pack of 30, by Global Napi Pharmaceuticals (Egypt); fixed-dose ACE inhibitor/thiazide diuretic combination.

• HypertensionPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most frequent: dizziness (7.5%), headache (5.2%), cough (3.9%), fatigue (3.7%), orthostatic effects (3.2%).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to the product; history of angioedema related to previous ACE inhibitor treatment; hereditary or idiopathic angioedema.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Anuria or hypersensitivity to other sulfonamide-derived drugs (hydrochlorothiazide component).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Combination with a neprilysin inhibitor (sacubitril) or within 36 hours of switching; aliskiren co-administration in patients with diabetes.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hyperkalaemia occurred in about 1.4% of patients; risk factors include renal insufficiency, diabetes, potassium-sparing diuretics, potassium supplements and salt substitutes.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Acute myopia and secondary angle-closure glaucoma (hydrochlorothiazide): discontinue promptly if decreased visual acuity or ocular pain occurs.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Non-melanoma skin cancer: patients taking hydrochlorothiazide should protect skin from the sun and undergo regular skin cancer screening.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• LithiumLithium generally should not be given with thiazides.DailyMed (U.S. National Library of Medicine)
• Potassium-sparing diuretics, potassium supplements, salt substitutesUse cautiously, if at all, with frequent potassium monitoring.DailyMed (U.S. National Library of Medicine)
• Neprilysin inhibitors (sacubitril)Contraindicated (angioedema risk).DailyMed (U.S. National Library of Medicine)

• Boxed warning (fetal toxicity): when pregnancy is detected, discontinue as soon as possible; drugs acting directly on the renin-angiotensin system can cause injury and death to the developing fetus.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Thiazides appear in human milk; lisinopril is present in rat milk. Because of potential serious adverse reactions in nursing infants, decide whether to discontinue nursing or the drug.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Lisinopril: Inhibits angiotensin-converting enzyme, lowering angiotensin II and aldosterone.
• Hydrochlorothiazide: Promotes renal excretion of sodium and chloride, reducing intravascular volume.