سعر ليسيتنس 20/12.5مجم 20قرص 2023

Lisitens tablets, hydrochlorothiazide 12.5 mg + lisinopril 20 mg, pack of 30 (3 strips; Hi-Pharm, Egypt); ACE inhibitor combined with a thiazide diuretic for hypertension.

• Hypertension, to lower blood pressure; not indicated for initial therapy.Population: AdultsDailyMed (U.S. National Library of Medicine)

• Most frequent in controlled trials: dizziness 7.5%, headache 5.2%, cough 3.9%, fatigue 3.7% and orthostatic effects 3.2%; discontinuation in 4.4%, mainly for dizziness, cough, fatigue and muscle cramps.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• History of angioedema related to previous ACE-inhibitor treatment; hereditary or idiopathic angioedema; hypersensitivity to the product.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Anuria or hypersensitivity to other sulfonamide-derived drugs (hydrochlorothiazide component).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Combination with a neprilysin inhibitor (sacubitril); do not give within 36 hours of switching to or from sacubitril/valsartan; do not co-administer aliskiren in patients with diabetes.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Fetal toxicity: renin-angiotensin system drugs can injure or kill the developing fetus; discontinue as soon as pregnancy is detected.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Angioedema of the face, extremities, lips, tongue, glottis or larynx, and intestinal angioedema, may occur; stop and treat promptly; airway involvement can be fatal.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hyperkalaemia (serum potassium >5.7 mEq/L) occurred in about 1.4% of hypertensive patients in trials; risk factors are renal insufficiency, diabetes and potassium-sparing diuretics, potassium supplements or potassium-containing salt substitutes.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Potassium-sparing diuretics, potassium supplements, potassium-containing salt substitutesIncrease the risk of hyperkalaemia; use cautiously, if at all, with frequent potassium monitoring.DailyMed (U.S. National Library of Medicine)
• LithiumLithium generally should not be given with thiazides because of the risk of lithium toxicity.DailyMed (U.S. National Library of Medicine)
• Aliskiren, angiotensin receptor blockers or other ACE inhibitors (dual RAS blockade)Dual blockade increases hypotension, hyperkalaemia and renal-function changes; avoid combined use and monitor blood pressure, renal function and electrolytes.DailyMed (U.S. National Library of Medicine)

• When pregnancy is detected, discontinue as soon as possible: drugs acting on the renin-angiotensin system in the second and third trimesters reduce fetal renal function and increase fetal and neonatal morbidity and death (oligohydramnios, lung hypoplasia, skeletal deformations).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Not known whether lisinopril passes into human milk (it is present in rat milk); thiazides appear in human milk; decide whether to stop nursing or the drug.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hydrochlorothiazide: Promotes renal excretion of sodium and chloride, reducing intravascular volume.
• Lisinopril: Inhibits angiotensin-converting enzyme, reducing angiotensin II formation and aldosterone secretion.