سعر سوبرول بلس 5/12.5مجم 20 قرص 2022

Bisoprolol fumarate 5 mg + hydrochlorothiazide 12.5 mg film-coated tablets, pack of 20 (2 strips); EVA Pharma, Egypt.

• Treatment of arterial hypertension in adults when monotherapy is insufficient.Population: AdultsFederal Agency for Medicines and Health Products (FAGG-AFMPS), Belgium

• Common: dizziness, headache and fatigue (mainly at start of treatment, usually mild and resolving within 1-2 weeks) and gastrointestinal complaints (nausea, vomiting, diarrhoea, constipation); fluid and electrolyte disturbances with long-term hydrochlorothiazide.International label, equivalent formulation · Federal Agency for Medicines and Health Products (FAGG-AFMPS), Belgium

• Hypersensitivity to the active substances, other thiazides, sulfonamides or excipients; acute heart failure or decompensation requiring IV inotropes; cardiogenic shock; second/third-degree AV block (without pacemaker); sick sinus syndrome; sinoatrial block; symptomatic bradycardia.International label, equivalent formulation · Federal Agency for Medicines and Health Products (FAGG-AFMPS), Belgium
• Severe bronchial asthma; severe peripheral arterial occlusive disease or Raynaud syndrome; untreated phaeochromocytoma; severe renal (CrCl 30 mL/min or less) or hepatic insufficiency; metabolic acidosis; refractory hypokalaemia; severe hyponatraemia; hypercalcaemia; gout.International label, equivalent formulation · Federal Agency for Medicines and Health Products (FAGG-AFMPS), Belgium

• Do not stop bisoprolol abruptly; use cautiously in heart failure, diabetes with fluctuating glucose (hypoglycaemia may be masked), strict fasting, first-degree AV block, Prinzmetal angina, peripheral arterial disease, hypovolaemia and impaired liver function.International label, equivalent formulation · Federal Agency for Medicines and Health Products (FAGG-AFMPS), Belgium
• Hydrochlorothiazide increases the risk of non-melanoma skin cancer with cumulative dose; advise skin checks and sun protection. Photosensitivity may occur.International label, equivalent formulation · Federal Agency for Medicines and Health Products (FAGG-AFMPS), Belgium
• Long-term hydrochlorothiazide can cause hypokalaemia, hyponatraemia, hypomagnesaemia, hypochloraemia and hypercalcaemia; hypokalaemia favours serious arrhythmias such as torsade de pointes. Gout attacks may increase in hyperuricaemia.International label, equivalent formulation · Federal Agency for Medicines and Health Products (FAGG-AFMPS), Belgium

• LithiumNot recommended: reduced lithium excretion increases cardiotoxic and neurotoxic effects.Federal Agency for Medicines and Health Products (FAGG-AFMPS), Belgium
• Verapamil- and diltiazem-type calcium antagonistsNot recommended: negative effect on contractility and AV conduction; IV verapamil may cause marked hypotension and AV block.Federal Agency for Medicines and Health Products (FAGG-AFMPS), Belgium
• Centrally acting antihypertensives (clonidine, methyldopa, moxonidine, rilmenidine)Not recommended: further fall in heart rate and output; abrupt withdrawal increases rebound hypertension risk.Federal Agency for Medicines and Health Products (FAGG-AFMPS), Belgium

• Not recommended during pregnancy unless clearly necessary: bisoprolol may reduce placental perfusion (growth retardation, intrauterine death, abortion, early labour) and cause neonatal hypoglycaemia and bradycardia; hydrochlorothiazide may cause fetoplacental ischaemia with risk of fetal hypotrophy and probably neonatal thrombocytopenia.International label, equivalent formulation · Federal Agency for Medicines and Health Products (FAGG-AFMPS), Belgium
• Not recommended during breastfeeding: bisoprolol may and hydrochlorothiazide does pass into breast milk; hydrochlorothiazide may reduce milk production.International label, equivalent formulation · Federal Agency for Medicines and Health Products (FAGG-AFMPS), Belgium

• Bisoprolol fumarate: Beta-1-selective adrenoceptor blocker without significant intrinsic sympathomimetic activity; lowers heart rate and cardiac output.
• Hydrochlorothiazide: Thiazide diuretic that increases renal excretion of sodium and chloride, reducing plasma volume.