سعر لودوز 6.25/5 مجم 30 قرص 2022

Lodoz 5/6.25 mg 30 f.c. tabs: bisoprolol fumarate 5 mg + hydrochlorothiazide 6.25 mg film-coated tablets (Amoun, under licence from Merck KGaA, Germany); beta-1 blocker/thiazide combination for hypertension.

• Management of hypertensionPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Generally mild and transient. In US controlled trials with bisoprolol 2.5-40 mg/HCTZ 6.25 mg the most frequent adverse experiences included dizziness (5.1%), fatigue (4.6%), headache (4.5%), diarrhoea (4.3%), myalgia (2.4%), cough (2.2%) and URI (2.1%).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Cardiogenic shock, overt cardiac failure, second- or third-degree AV block, marked sinus bradycardia, anuria, and hypersensitivity to either component or to other sulfonamide-derived drugs.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Beta-blockers should generally be avoided in overt congestive failure; consider discontinuation at the first signs of heart failure.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Abrupt cessation may exacerbate angina and has been followed by myocardial infarction or ventricular arrhythmia in coronary artery disease; taper over about 1 week (label: about 2 weeks for planned withdrawal).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Patients with bronchospastic disease should in general not receive beta-blockers; if necessary use the lowest dose with a beta-2 agonist available.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Other beta-blockers; catecholamine-depleting drugs (reserpine, guanethidine)Do not combine with other beta-blockers; monitor closely with catecholamine depleters (excessive reduction of sympathetic activity).DailyMed (U.S. National Library of Medicine)
• ClonidineIf clonidine is to be stopped, discontinue this product several days before clonidine withdrawal.DailyMed (U.S. National Library of Medicine)
• Verapamil, diltiazem, disopyramide and other myocardial depressants/AV-conduction inhibitors; digitalisUse with caution; additive slowing of AV conduction and heart rate (bradycardia).DailyMed (U.S. National Library of Medicine)

• Combination not teratogenic in rats/rabbits at high multiples of the maximum human dose. Thiazides cross the placenta; hazards include fetal or neonatal jaundice, pancreatitis and thrombocytopenia; weigh anticipated benefit against possible fetal hazards.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Not studied in nursing mothers; thiazides are excreted in human milk and small amounts of bisoprolol (<2% of dose) were found in rat milk; decide whether to discontinue nursing or the drug.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Bisoprolol fumarate: Beta-1-selective adrenoceptor blocking agent without significant membrane-stabilizing or intrinsic sympathomimetic activity at therapeutic doses.
• Hydrochlorothiazide: Thiazide diuretic that inhibits sodium and chloride reabsorption in the distal renal tubule, increasing their excretion.