سعر سبيركس بلس 20 قرص Spiramycin 1.5 M.وحدة دولية. 2025

Spirex Plus film-coated tablets (Medical Union Pharmaceuticals, Egypt), pack of 20: spiramycin 1.5 MIU (379 mg) + metronidazole 250 mg per tablet; a macrolide-nitroimidazole combination for periodontal/oral and upper respiratory infections.

• Acute and chronic periodontal infections: periodontitis, gingivitis and stomatitis.Medical Union Pharmaceuticals (MUP) leaflet, copy hosted by Medica RCP (Lebanon)
• Upper respiratory tract infections: pharyngitis, tonsillitis, sinusitis and otitis media.Medical Union Pharmaceuticals (MUP) leaflet, copy hosted by Medica RCP (Lebanon)
• Prevention of local post-operative infectious complications in odontogenic infection.Medical Union Pharmaceuticals (MUP) leaflet, copy hosted by Medica RCP (Lebanon)

• Dermatologic: rash, urticaria, pruritus. Gastrointestinal: nausea, vomiting, diarrhoea. Hepatic: increased transaminases.Egyptian label · Medical Union Pharmaceuticals (MUP) leaflet, copy hosted by Medica RCP (Lebanon)
• Metronidazole: epigastric pain, nausea, vomiting, diarrhoea, oral mucositis, taste disturbance, anorexia, reversible pancreatitis, tongue discoloration; angioedema, anaphylactic shock; peripheral sensory neuropathy, headache, convulsions, vertigo, encephalopathy, acute cerebellar syndrome, aseptic meningitis; psychotic disorder, confusion, hallucinations; transient visual disturbances, optic neuropathy; agranulocytosis, neutropenia, thrombocytopenia; raised liver enzymes, cholestatic or mixed hepatitis, liver failure; rash, pruritus, urticaria, pustular eruptions, Stevens-Johnson syndrome, toxic epidermal necrolysis; fever.General active-ingredient information · Vademecum (Vidal Vademecum Spain; Egypt drug database)

• Hypersensitivity to spiramycin or metronidazole.Egyptian label · Medical Union Pharmaceuticals (MUP) leaflet, copy hosted by Medica RCP (Lebanon)
• Metronidazole: hypersensitivity to imidazoles.General active-ingredient information · Vademecum (Vidal Vademecum Spain; Egypt drug database)

• Caution in patients with a history of blood dyscrasia, because the drug can cause leukopenia.Egyptian label · Medical Union Pharmaceuticals (MUP) leaflet, copy hosted by Medica RCP (Lebanon)
• Caution in peripheral neuropathy and seizure disorders, which can be exacerbated.Egyptian label · Medical Union Pharmaceuticals (MUP) leaflet, copy hosted by Medica RCP (Lebanon)
• Avoid alcohol and alcohol-containing medicines during therapy and for at least 48 hours after the last dose (disulfiram-like reaction).Egyptian label · Medical Union Pharmaceuticals (MUP) leaflet, copy hosted by Medica RCP (Lebanon)

• AlcoholDisulfiram-like reaction with concomitant alcohol.Medical Union Pharmaceuticals (MUP) leaflet, copy hosted by Medica RCP (Lebanon)
• Oral anticoagulantsEffect of oral anticoagulants is enhanced by metronidazole.Medical Union Pharmaceuticals (MUP) leaflet, copy hosted by Medica RCP (Lebanon)
• DisulfiramPsychotic reaction with metronidazole; stop disulfiram 2 weeks before treatment.Vademecum (Vidal Vademecum Spain; Egypt drug database)

• Pregnancy and lactation: give only if the potential benefit outweighs the potential risk to the fetus or baby; metronidazole readily crosses the placenta and is secreted into breast milk.Egyptian label · Medical Union Pharmaceuticals (MUP) leaflet, copy hosted by Medica RCP (Lebanon)
• Use may be considered during pregnancy if needed, whatever the term: analysis of a large number of exposed pregnancies showed no particular malformative or foetotoxic effect of metronidazole (only epidemiological studies could confirm absence of risk; no teratogenicity in animals), and wide use of spiramycin in pregnancy has not shown malformative or foetotoxic effects.International label, same formulation · Asafar (Moroccan medicines database based on AMMPS/ANAM data)
• Metronidazole is secreted into breast milk; use only if the potential benefit outweighs the risk to the baby.Egyptian label · Medical Union Pharmaceuticals (MUP) leaflet, copy hosted by Medica RCP (Lebanon)

• Spiramycin: Macrolide: binds the 50S subunit of bacterial ribosomes, blocking transpeptidation and inhibiting protein synthesis; primarily bacteriostatic, possibly bactericidal against more sensitive strains at high concentrations.
• Metronidazole: Nitroimidazole: reduced intracellularly in anaerobic and microaerophilic bacteria and protozoa; the reduction product disrupts DNA and inhibits its synthesis (bactericidal).

Store at a temperature not exceeding 30 °C in a dry place.