سعر رواتريجين 200مجم 10 اقراص 2022

Lamotrigine 200 mg tablets, pack of 10 (Al Rowad Pharmaceutical Industrial Co., Egypt); phenyltriazine antiepileptic.

• Epilepsy, adjunctive therapy (age 2 years and older): partial-onset seizures, primary generalised tonic-clonic seizures, Lennox-Gastaut syndromePopulation: Patients aged 2 years and olderDailyMed (U.S. National Library of Medicine)
• Epilepsy, conversion to monotherapy in partial-onset seizures (age 16 years and older)Population: Patients aged 16 years and olderDailyMed (U.S. National Library of Medicine)
• Maintenance treatment of bipolar I disorderPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Hypersensitivity (e.g. rash, angioedema, acute urticaria, extensive pruritus, mucosal ulceration) to lamotrigine or its ingredients.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: serious skin rashes including Stevens-Johnson syndrome (about 0.3-0.8% in children aged 2-17 and 0.08-0.3% in adults); discontinue at the first sign of rash unless clearly not drug-related.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hemophagocytic lymphohistiocytosis and multiorgan hypersensitivity (DRESS) may occur; evaluate promptly and discontinue if no alternative cause.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• ValproateValproate inhibits lamotrigine glucuronidation, increasing its levels; lower doses and slower escalation are required.DailyMed (U.S. National Library of Medicine)
• Estrogen-containing oral contraceptivesEstrogen-containing contraceptives increase lamotrigine clearance; maintenance dose adjustments are needed when starting or stopping them.DailyMed (U.S. National Library of Medicine)

• Registry and epidemiological data have not detected an increased frequency of major congenital malformations with lamotrigine compared with the general population; levels may change during pregnancy and postpartum.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Lamotrigine is present in human milk; breastfed infants may have high serum levels and events such as rash, apnoea, drowsiness, poor sucking and poor weight gain have been reported; monitor infants.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Lamotrigine: Precise mechanism unknown; inhibits voltage-sensitive sodium channels, stabilising neuronal membranes and modulating release of excitatory amino acids (glutamate).