سعر صانيدارون 150مجم/3مل 5 امبولات 2024

Sunnydarone amiodarone hydrochloride 150 mg/3 mL ampoules for intravenous use, pack of 5 (Sunny Medical, Egypt); class III antiarrhythmic.

• Initiation of treatment and prophylaxis of frequently recurring ventricular fibrillation and haemodynamically unstable ventricular tachycardia in patients refractory to other therapy.DailyMed (U.S. National Library of Medicine)
• VT/VF patients for whom oral amiodarone is indicated but who cannot take oral medication.DailyMed (U.S. National Library of Medicine)

• Most important: hypotension, asystole/cardiac arrest/PEA, cardiogenic shock, congestive heart failure, bradycardia, liver function test abnormalities, VT and AV block; also torsade de pointes.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to any component, including iodine.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Cardiogenic shock.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Marked sinus bradycardia.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypotension is the most common adverse reaction (16%), related to infusion rate; slow the infusion and give standard support; may be refractory and fatal.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Bradycardia and AV block: slow or stop the infusion; a pacemaker may be required.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hepatic injury: acute hepatocellular necrosis with hepatic coma, renal failure and death has occurred, notably with loading infusions at much higher concentrations/rates than recommended; monitor for progressive liver injury.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• QT-prolonging drugsIncreased risk of torsade de pointes; generally avoid concomitant use.DailyMed (U.S. National Library of Medicine)
• Digoxin, beta blockers, verapamil, diltiazem, ivabradine, clonidinePotentiated bradycardia, sinus arrest and AV block; monitor heart rate.DailyMed (U.S. National Library of Medicine)
• WarfarinPotentiated anticoagulant response (INR may rise ~100% within 3-4 days); reduce warfarin dose by one-third to one-half and monitor INR closely.DailyMed (U.S. National Library of Medicine)

• Can cause fetal harm; amiodarone and desethylamiodarone cross the placenta; reported risks include neonatal bradycardia, QT prolongation and neonatal hypothyroidism; use only if the potential benefit justifies the risk.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Advise mothers to discontinue breastfeeding.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Amiodarone: Prolongs the cardiac action potential and refractoriness (class III effect) by blocking myocardial potassium channels; also blocks sodium channels at rapid rates, has non-competitive antisympathetic action and slows nodal conduction (class I, II and IV-like effects).