سعر ستريم 400/80مجم 20*10 اقراص 2025

Co-trimoxazole (sulfamethoxazole + trimethoprim) 400 mg/80 mg tablet by Memphis (Egypt); 20 strips x 10 tablets (200 tablets).

• Urinary tract infections due to susceptible organismsPopulation: Adults and children >=2 monthsDailyMed (U.S. National Library of Medicine)
• Acute otitis media in paediatric patients due to susceptible organismsPopulation: Children >=2 monthsDailyMed (U.S. National Library of Medicine)
• Acute exacerbations of chronic bronchitis in adultsPopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most common: gastrointestinal disturbances (nausea, vomiting, anorexia) and allergic skin reactions (rash, urticaria).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Contraindicated in hypersensitivity to trimethoprim or sulfonamides, history of drug-induced immune thrombocytopenia, megaloblastic anaemia due to folate deficiency, infants under 2 months, marked hepatic damage, severe renal insufficiency when renal function cannot be monitored, and with dofetilide.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Serious and sometimes fatal reactions including SJS/TEN, DRESS, fulminant hepatic necrosis, agranulocytosis, aplastic anaemia and other blood dyscrasias have occurred; discontinue at first appearance of rash.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hyperkalaemia and severe hyponatraemia may occur, especially at high doses, in renal impairment or with potassium-raising drugs; monitor electrolytes.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• WarfarinMay prolong prothrombin time; monitor PT/INR.DailyMed (U.S. National Library of Medicine)
• PhenytoinMay inhibit phenytoin hepatic metabolism; monitor phenytoin levels.DailyMed (U.S. National Library of Medicine)
• DofetilideConcomitant use contraindicated.DailyMed (U.S. National Library of Medicine)

• Some epidemiologic studies suggest an association with congenital malformations; use in pregnancy only if potential benefit justifies potential risk to the fetus.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Excreted in breast milk (about 2-5% of infant dose); caution, especially with jaundiced, ill, stressed or premature infants (kernicterus risk).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Sulfamethoxazole: Competes with PABA to inhibit bacterial dihydropteroate synthase (folate synthesis).
• Trimethoprim: Inhibits bacterial dihydrofolate reductase.