سعر كوتريل 400/80مجم 20 قرص 2026

Cotril 400/80mg 20 tab.: Sulphamethoxazole+trimethoprim (El nasr).

• US Bactrim (SMX/TMP): labeled for susceptible infections including UTI, acute otitis media (pediatric), chronic bronchitis exacerbation, shigellosis, PCP treatment/prophylaxis, traveler's diarrhea — confirm Egyptian leaflet.Population: Adults / labeled pediatricsDailyMed (U.S. National Library of Medicine)

• GI upset, rash, and allergic reactions common; serious SCARs and blood dyscrasias reported (US Bactrim).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to trimethoprim or sulfonamides; drug-induced immune thrombocytopenia history; megaloblastic anemia due to folate deficiency; pediatric patients <2 months; marked hepatic damage; severe renal insufficiency when function cannot be monitored; concomitant dofetilide (US Bactrim).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Embryo-fetal toxicity; severe cutaneous adverse reactions (SJS/TEN/DRESS); blood dyscrasias; fulminant hepatic necrosis; anaphylaxis; C. difficile-associated diarrhea; hyperkalemia (US Bactrim).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• DofetilideMajorConcomitant administration contraindicated (US Bactrim).DailyMed (U.S. National Library of Medicine)

• US Bactrim: embryo-fetal toxicity warning; sulfonamides may cause kernicterus — avoid near term; weigh benefit/risk.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Sulfamethoxazole: Competes with PABA to inhibit dihydropteroate synthase in folate synthesis.
• Trimethoprim: Inhibits bacterial dihydrofolate reductase, blocking tetrahydrofolate production.