سعر سيبتازول 400/80مجم 20*10 اقراص 2025

Septazole 400/80 mg tablets contains sulfamethoxazole + trimethoprim (co-trimoxazole), a combination antibacterial by Alexandria Co. for Pharmaceuticals and Chemical Industries, listed under antibiotics in Egypt.

• Urinary tract infections due to susceptible E. coli, Klebsiella, Enterobacter, Morganella morganii, Proteus mirabilis and P. vulgarisPopulation: Adults and children >= 2 monthsDailyMed (U.S. National Library of Medicine)
• Acute otitis media in pediatric patients due to susceptible S. pneumoniae or H. influenzae when the combination offers an advantagePopulation: Children >= 2 monthsDailyMed (U.S. National Library of Medicine)
• Acute exacerbations of chronic bronchitis in adults due to susceptible S. pneumoniae or H. influenzaePopulation: AdultsDailyMed (U.S. National Library of Medicine)

• Most common: gastrointestinal disturbances (nausea, vomiting, anorexia) and allergic skin reactions (rash, urticaria); serious skin reactions and blood dyscrasias are reported.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Known hypersensitivity to trimethoprim or sulfonamides; history of drug-induced immune thrombocytopenia with trimethoprim and/or sulfonamides; megaloblastic anaemia due to folate deficiency; infants younger than 2 months; marked hepatic damage; severe renal insufficiency when renal function cannot be monitored; concomitant dofetilide.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Embryo-fetal toxicity: some epidemiological studies suggest increased risk of congenital malformations (neural tube, cardiovascular, urinary tract defects, oral clefts, club foot).International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Serious or fatal reactions: severe cutaneous adverse reactions (SJS, TEN, DRESS, AFND, AGEP), fulminant hepatic necrosis, agranulocytosis, aplastic anaemia and other blood dyscrasias, respiratory hypersensitivity; stop at the first rash or sign of a serious reaction.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Hyperkalaemia (especially with high doses, renal impairment, potassium metabolism disorders or other potassium-raising drugs), severe hyponatraemia, thrombocytopenia, hemophagocytic lymphohistiocytosis and C. difficile-associated diarrhoea have been reported; not for group A streptococcal infections.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• DofetilideConcomitant use is contraindicated.DailyMed (U.S. National Library of Medicine)
• Warfarin (CYP2C9 substrate)May prolong prothrombin time; reassess coagulation (PT/INR).DailyMed (U.S. National Library of Medicine)
• MethotrexateAvoid concurrent use: increased free methotrexate concentrations.DailyMed (U.S. National Library of Medicine)

• Because sulfamethoxazole/trimethoprim may interfere with folic acid metabolism, use during pregnancy only if the potential benefit justifies the potential risk to the fetus; patients should be advised of possible fetal hazards.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Levels in breast milk are about 2-5% of the recommended infant dose; use with caution when nursing, especially jaundiced, ill, stressed or premature infants (risk of bilirubin displacement and kernicterus).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Sulfamethoxazole: Competes with PABA to inhibit bacterial dihydropteroate synthase (folate synthesis).
• Trimethoprim: Inhibits bacterial dihydrofolate reductase, blocking tetrahydrofolate production.