سعر ثيو Theo‏ 300مجم اس ار 10 كبسولات 2026

Theophylline 300 mg sustained-release capsules, pack of 10, by GlaxoSmithKline (Egypt) (Egypt).

• At peak levels <20 mcg/mL mainly transient caffeine-like effects (nausea, vomiting, headache, insomnia); above 20 mcg/mL persistent vomiting, cardiac arrhythmias and intractable seizures that can be lethal.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Hypersensitivity to theophylline or other product components.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Use with extreme caution in active peptic ulcer disease, seizure disorders and cardiac arrhythmias (not bradyarrhythmias).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Narrow therapeutic range: conditions that reduce clearance (e.g. liver disease, heart failure, fever, hypothyroidism, sepsis, smoking cessation, interacting drugs) can cause severe or fatal toxicity unless the dose is reduced; withhold doses and measure serum level if nausea/vomiting or other toxicity signs appear.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Metabolism inhibitors (e.g. cimetidine, erythromycin, tacrine)Adding them reduces theophylline clearance and can cause toxicity; dose reduction needed.DailyMed (U.S. National Library of Medicine)
• Metabolism inducers (e.g. carbamazepine, rifampin)Stopping a concurrent inducer raises theophylline levels.DailyMed (U.S. National Library of Medicine)

• Teratogenic effects in animal studies at high doses; no adequate studies in pregnant women.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Excreted into breast milk at about the maternal serum concentration; may cause irritability or mild toxicity in the infant.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Theophylline: Relaxes airway smooth muscle (bronchodilation) and suppresses airway responsiveness to stimuli; bronchodilation is thought to be mediated by inhibition of phosphodiesterase isozymes PDE III and, to a lesser extent, PDE IV (US label; mechanisms not known with certainty).