سعر رومافين 75مجم اس ار 10 كبسول 2022

Rheumafen 75 mg SR capsules (75 mg diclofenac sodium, sustained-release capsule) is an Egyptian NSAID product marketed by GlaxoSmithKline (Egypt).

• Relief of the signs and symptoms of osteoarthritis.DailyMed (U.S. National Library of Medicine)
• Relief of the signs and symptoms of rheumatoid arthritis.DailyMed (U.S. National Library of Medicine)
• Acute or long-term relief of the signs and symptoms of ankylosing spondylitis.DailyMed (U.S. National Library of Medicine)

• Most frequent (about 1-10%): abdominal pain, constipation, diarrhoea, dyspepsia, flatulence, heartburn, nausea, vomiting, GI ulcers, abnormal renal function, anaemia, dizziness, oedema, elevated liver enzymes, headache, increased bleeding time, pruritus, rash, tinnitus.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Active gastric or intestinal ulcer, bleeding or perforation, or history of recurrent peptic ulceration/haemorrhage or NSAID-related GI bleeding.International label, same formulation · electronic medicines compendium (emc)
• Severe hepatic, renal or cardiac failure; established congestive heart failure (NYHA II-IV), ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease; last trimester of pregnancy.International label, same formulation · electronic medicines compendium (emc)
• Known hypersensitivity (e.g. anaphylactic reactions, serious skin reactions) to diclofenac or any component.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: NSAIDs increase the risk of serious cardiovascular thrombotic events (myocardial infarction, stroke), which can be fatal; risk may occur early and increase with duration.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Boxed warning: NSAIDs increase the risk of serious GI bleeding, ulceration and perforation, which can be fatal and occur without warning; elderly and those with prior ulcer/GI bleeding are at greater risk.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Other labelled warnings include hepatotoxicity, hypertension, heart failure and oedema, renal toxicity and hyperkalaemia, anaphylactic reactions, serious skin reactions including DRESS, and haematologic toxicity.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Anticoagulants (e.g. warfarin), antiplatelets (e.g. aspirin), SSRIs, SNRIsIncreased risk of bleeding; monitor for signs of bleeding.DailyMed (U.S. National Library of Medicine)
• Aspirin (analgesic doses)No added benefit and more GI adverse reactions; concomitant use not generally recommended. Diclofenac is not a substitute for low-dose aspirin for cardiovascular protection.DailyMed (U.S. National Library of Medicine)

• Use of NSAIDs can cause premature closure of the fetal ductus arteriosus and fetal renal dysfunction leading to oligohydramnios; limit dose and duration between about 20 and 30 weeks of gestation and avoid at about 30 weeks and later.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Diclofenac may be present in human milk; weigh the benefits of breastfeeding against the mother's clinical need and potential adverse effects on the infant.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Diclofenac sodium: Inhibits cyclo-oxygenase (COX-1 and COX-2), reducing prostaglandin synthesis.