سعر يونيستين Unistin‏ 50مجم فيال وريد 50 مل 2026

Cisplatin 50 mg vial for intravenous infusion (platinum-based cytotoxic chemotherapy).

• Nephrotoxicity, ototoxicity, peripheral neuropathy, myelosuppression and severe nausea/vomiting are characteristic.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Pre-existing renal impairment, myelosuppression, hearing impairment, or history of allergy to cisplatin or other platinum compounds.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Dose-related, cumulative nephrotoxicity is the major dose-limiting toxicity; renal function must return to normal before the next dose.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• AnticonvulsantsPlasma anticonvulsant levels may become subtherapeutic during cisplatin therapy.DailyMed (U.S. National Library of Medicine)
• Pyridoxine with altretamineResponse duration was adversely affected when pyridoxine was combined with altretamine and cisplatin in advanced ovarian cancer.DailyMed (U.S. National Library of Medicine)

• Can cause fetal harm; historical FDA Pregnancy Category D (see label warnings).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Cisplatin: Forms intra-strand DNA cross-links (primarily guanine N7), inhibiting DNA replication and transcription, leading to apoptosis of susceptible tumour cells.