سعر يونيتاكسيل Unitaxel‏ 30مجم/5مل فيال 2026

Paclitaxel 6 mg/mL (30 mg/5 ml) concentrate, 150 mg vial for intravenous infusion (taxane cytotoxic chemotherapy).

• Neutropenia, alopecia, peripheral neuropathy, myalgia/arthralgia, nausea/vomiting, mucositis and hypersensitivity reactions are common.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• History of hypersensitivity to paclitaxel or other drugs formulated in polyoxyl 35 castor oil; baseline neutrophils <1,500/mm3 in solid tumours or <1,000/mm3 in AIDS-related Kaposi sarcoma.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: anaphylaxis and severe hypersensitivity (fatal in some cases) occurred in 2-4% of patients despite premedication; bone-marrow suppression (neutropenia) is dose-limiting.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• CisplatinGive paclitaxel before cisplatin; cisplatin first reduces paclitaxel clearance by about 20% and increases myelosuppression.DailyMed (U.S. National Library of Medicine)
• CYP2C8/CYP3A4 inhibitors or inducersPaclitaxel is metabolised by CYP2C8 and CYP3A4; exposure may change with inhibitors or inducers; use caution.DailyMed (U.S. National Library of Medicine)

• Can cause fetal harm when administered to a pregnant woman; avoid pregnancy during treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Frequent peripheral blood counts; do not retreat until neutrophils recover; monitor for hypersensitivity and cardiac conduction abnormalities during infusion.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Paclitaxel: Antimicrotubule agent that promotes microtubule assembly by enhancing tubulin polymerisation, forming stable non-functional microtubules and disrupting the dynamic equilibrium of the microtubule system needed for mitosis.