سعر يونيتوبفين Unitopfin‏ 250مجم 7 اقراص 2026

Terbinafine 250 mg film-coated tablets, pack of 7.

• Most frequent in trials: gastrointestinal symptoms (diarrhea, dyspepsia, abdominal pain), liver test abnormalities, rashes, urticaria, pruritus and taste disturbances; headache.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Chronic or active liver disease; history of allergic reaction to oral terbinafine.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hepatotoxicity including liver failure leading to transplant or death; perform liver function tests before treatment and monitor periodically.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Taste and smell disturbance, depressive symptoms, hematologic effects (neutropenia), severe skin reactions (SJS/TEN/DRESS), lupus erythematosus and thrombotic microangiopathy have been reported.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• CYP2D6 substrates (tricyclic antidepressants, SSRIs, beta-blockers, class 1C antiarrhythmics, MAO-B inhibitors)Terbinafine inhibits CYP2D6; co-administration requires careful monitoring and may need dose reduction of the CYP2D6 substrate.DailyMed (U.S. National Library of Medicine)

• Postmarketing data are insufficient to evaluate a drug-associated risk; animal studies at up to 12-23 times the maximum human dose showed no fetal harm.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Terbinafine is present in human milk after oral administration; no data on effects on the breastfed child or milk production.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Terbinafine: Inhibits fungal squalene epoxidase, blocking ergosterol synthesis (fungicidal).