سعر تيربيفنجين Terbifungin‏ 250مجم 14 اقراص 2026

Terbinafine 250 mg tablets, pack of 14 (Global Napi Pharmaceuticals, Egypt); oral allylamine antifungal.

• Most frequent in trials: gastrointestinal symptoms (diarrhea, dyspepsia, abdominal pain), liver test abnormalities, rash, urticaria, pruritus and taste disturbance.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Chronic or active liver disease; history of allergic reaction to oral terbinafine (risk of anaphylaxis).International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Hepatotoxicity: liver failure, some leading to transplant or death, has occurred with and without pre-existing liver disease; perform liver function tests before treatment.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Taste and smell disturbance (may be prolonged or permanent), depressive symptoms, decreases in lymphocyte counts and severe neutropenia, serious skin/hypersensitivity reactions including SJS/TEN and DRESS, lupus erythematosus and thrombotic microangiopathy have been reported; discontinue if they occur.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Drugs metabolised by CYP2D6 (tricyclic antidepressants, SSRIs, beta-blockers, class 1C antiarrhythmics, MAO-B inhibitors)Terbinafine inhibits CYP2D6 (desipramine exposure about doubled); monitor and consider dose reduction of the CYP2D6 substrate.DailyMed (U.S. National Library of Medicine)

• Postmarketing data are insufficient to evaluate drug-associated risk; no malformations or fetal harm in rat and rabbit studies at up to 23 and 12 times the maximum recommended human dose.International label, same formulation · DailyMed (U.S. National Library of Medicine)
• Terbinafine is present in human milk after oral administration; no data on effects on the breastfed child or milk production.International label, same formulation · DailyMed (U.S. National Library of Medicine)

• Terbinafine: Fungicidal; inhibits squalene epoxidase, blocking conversion of squalene to ergosterol (directory pharmacology note).