سعر Vixadep 150 mg sustained-release 60 film-coated tablets 2026

Vixadep: bupropion 150 mg sustained-release film-coated tablets (60), aminoketone antidepressant.

• Most common (5% or more and at least 2% above placebo): headache, dry mouth, nausea, insomnia, dizziness, pharyngitis, constipation, agitation, anxiety, abdominal pain, tinnitus, tremor, palpitation, myalgia, sweating, rash and anorexia.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Seizure disorder; current or prior bulimia or anorexia nervosa; abrupt discontinuation of alcohol, benzodiazepines, barbiturates or antiepileptic drugs; MAOIs (or within 14 days of stopping); starting in patients on linezolid or intravenous methylene blue.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: antidepressants increased suicidal thoughts and behaviours in children, adolescents and young adults; monitor all patients for worsening and emergence of suicidality. Also: neuropsychiatric events in smoking cessation use, dose-related seizure risk, hypertension, activation of mania/hypomania, psychosis and other neuropsychiatric reactions, angle-closure glaucoma.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• CYP2B6 inducers (ritonavir, lopinavir, efavirenz, carbamazepine, phenobarbital, phenytoin)May need a dose increase based on response, without exceeding the maximum dose.DailyMed (U.S. National Library of Medicine)
• CYP2D6 substrates (e.g. venlafaxine, nortriptyline, paroxetine, fluoxetine, haloperidol, risperidone, metoprolol, type 1C antiarrhythmics)Bupropion inhibits CYP2D6 and can increase their concentrations.DailyMed (U.S. National Library of Medicine)
• MAO inhibitorsContraindicated; allow 14 days between them.DailyMed (U.S. National Library of Medicine)

• Epidemiological data from first-trimester bupropion exposure have not identified an increased risk of congenital malformations overall.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Bupropion and metabolites are present in human milk; limited postmarketing data have not identified a clear association with adverse reactions in breastfed infants.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Bupropion: Mechanism not fully known; thought to involve noradrenergic and/or dopaminergic mechanisms (weak inhibitor of norepinephrine and dopamine reuptake) (US WELLBUTRIN SR label).