سعر انافرونيل 75مجم ممتد المفعول 20 قرص 2024

Clomipramine 75 mg sustained-release film-coated tablets (Anafranil SR brand, Novartis; distributed in Egypt by Sandoz), a tricyclic antidepressant; 20 tablets.

• Depression, obsessions and phobias (irrational fears)Population: AdultsHealth Products Regulatory Authority (HPRA)
• Muscular weakness (cataplexy) associated with repeated attacks of extreme sleepiness (narcolepsy) in adultsPopulation: AdultsHealth Products Regulatory Authority (HPRA)
• Depressive episodes, recurrent depressive disorders or major depression; cataplexy accompanying narcolepsy; obsessive-compulsive syndromes (adults)Population: AdultsSAHPRA PI/PIL repository

• Do not take if: heart attack within the last 3 months, serious heart disease, serious liver disease, glaucoma, difficulty passing urine, other mental illness apart from depression/obsessions/phobias, pregnancy or breast-feeding, age under 18, or MAOI use within the last 3 weeks.International label, same formulation · Health Products Regulatory Authority (HPRA)
• Combination therapy with other antidepressants; recent myocardial infarction, any degree of heart block or other cardiac dysrhythmias; congenital long QT syndrome; severe liver disease; hypokalaemia; narrow-angle glaucoma; retention of urine; mania.International label, same formulation · SAHPRA PI/PIL repository

• Boxed warning: antidepressants increased the risk of suicidal thinking and behavior in children, adolescents and young adults in short-term studies; monitor all patients for clinical worsening, suicidality and unusual changes in behavior.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Seizures were the most significant risk identified (cumulative incidence about 1.45% at 1 year at doses up to 300 mg/day); limit the daily dose to 250 mg in adults and 3 mg/kg (or 200 mg) in children and adolescents; use caution with a history of seizures or predisposing factors.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Talk to a doctor before use with epilepsy, overactive thyroid, adrenal tumour, low blood pressure, long-standing constipation, suicidal thoughts, heart rhythm problems, low blood potassium or planned ECT.International label, same formulation · Health Products Regulatory Authority (HPRA)

• MAO inhibitors (including moclobemide)ContraindicatedContraindicated; allow at least 14 days between an MAOI and clomipramine (either direction) because of severe interactions such as hypertensive crisis, hyperpyrexia, convulsions and serotonin syndrome.SAHPRA PI/PIL repository

• Do not take if pregnant, might become pregnant or breast-feeding. Some registry data suggest an increased risk of heart malformations with first-trimester use (2 in 100 pregnancies vs 1 in 100 in the general population).International label, same formulation · Health Products Regulatory Authority (HPRA)
• Safety in pregnancy has not been established; not recommended during pregnancy and in women of child-bearing potential not using contraception.International label, same formulation · SAHPRA PI/PIL repository
• Clomipramine passes into breast milk; nursing mothers should withdraw the medication or cease breastfeeding.International label, same formulation · SAHPRA PI/PIL repository

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