سعر بروثيادين 75 مجم 10 قرص. 2022

Dosulepin (dothiepin) 75 mg tablets; tricyclic antidepressant.

• Treatment of symptoms of depressive illness, especially where an anti-anxiety effect is required; only in patients intolerant of or unresponsive to alternative treatments.Population: Adultselectronic medicines compendium (emc)

• Atropine-like effects (dry mouth, accommodation disturbance, tachycardia, constipation, urinary hesitancy) are common early in treatment.International label, same formulation · electronic medicines compendium (emc)

• Recent myocardial infarction; any degree of heart block or other cardiac arrhythmias; mania; severe liver disease; hypersensitivity to dosulepin or any ingredient.International label, same formulation · electronic medicines compendium (emc)

• Low margin of safety between therapeutic and fatal doses: prescribe limited quantities, especially to patients at risk of suicide (maximum about two weeks of 75 mg/day at initiation and dose changes).International label, same formulation · electronic medicines compendium (emc)

• Monoamine oxidase inhibitorsDo not give concurrently or within 14 days of stopping an MAOI.electronic medicines compendium (emc)
• SSRIsAvoid co-administration; increased plasma tricyclic levels reported.electronic medicines compendium (emc)
• Alcohol, narcotic analgesics and other CNS depressantsEffects potentiated.electronic medicines compendium (emc)

• Avoid during pregnancy unless there are compelling reasons; safety in pregnancy not adequately studied.International label, same formulation · electronic medicines compendium (emc)
• Secreted in breast milk at levels unlikely to cause problems; use caution in breastfeeding women.International label, same formulation · electronic medicines compendium (emc)