سعر هيرفونال 40مجم/مل محلول بالفم 2022

Trimipramine 40 mg/ml oral solution (Herphonal; Temmler Pharma, Germany, marketed in Egypt by Tchero International). Bottle volume not stated by the sources.

• Relief of symptoms of depression (endogenous depression more likely to respond than other depressive states).Population: AdultsDailyMed (U.S. National Library of Medicine)

• Class-related tricyclic adverse reactions include hypotension, hypertension, tachycardia, palpitations and arrhythmias; confusional states (especially in the elderly); drowsiness, dizziness, weakness, fatigue and headache; anticholinergic effects; altered liver function or jaundice; and weight gain or loss. Abrupt stopping after prolonged therapy may cause nausea, headache and malaise.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Use with MAOIs intended to treat psychiatric disorders, or within 14 days of stopping either drug, is contraindicated (serotonin syndrome risk); starting trimipramine in a patient treated with linezolid or intravenous methylene blue is also contraindicated.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Hypersensitivity to tricyclic antidepressants (cross-sensitivity with other dibenzazepines is possible).General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Acute recovery period after myocardial infarction.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Boxed warning: antidepressants increased the risk of suicidal thinking and behaviour in children, adolescents and young adults in short-term studies; all patients should be monitored for clinical worsening, suicidality and unusual behaviour changes. Not approved for paediatric use.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Pupillary dilation may trigger an angle-closure glaucoma attack in patients with anatomically narrow angles without a patent iridectomy.General active-ingredient information · DailyMed (U.S. National Library of Medicine)
• Extreme caution in cardiovascular disease (conduction defects, arrhythmias, myocardial infarction, stroke, tachycardia) and caution in patients with a history of urinary retention because of anticholinergic effects.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• MAOIs (including linezolid and intravenous methylene blue)Contraindicated combination because of an increased risk of serotonin syndrome; allow at least 14 days between stopping one and starting the other.DailyMed (U.S. National Library of Medicine)
• CYP2D6 inhibitors (and CYP2D6 poor metabolizers)Reduced CYP2D6 activity can raise tricyclic antidepressant plasma concentrations substantially (up to about 8-fold AUC increases described for the class); dose adjustment may be needed.DailyMed (U.S. National Library of Medicine)

• Embryotoxicity and/or increased major anomalies were seen in rats or rabbits at doses about 20 times the human dose; there are no adequate and well-controlled studies in pregnant women, so use only if the potential benefit justifies the potential risk to the fetus.General active-ingredient information · DailyMed (U.S. National Library of Medicine)

• Trimipramine: Tricyclic antidepressant with an anxiety-reducing sedative component; its CNS mode of action is not known and it does not act by monoamine oxidase inhibition or primary CNS stimulation (US label).