سعر اميبرامين 25مجم 50 قرص 2024

Imipramine 25 mg oral tablets (pack of 50), a tricyclic antidepressant.

• Relief of symptoms of depression (endogenous depression more likely to respond)Population: AdultsDailyMed (U.S. National Library of Medicine)
• Temporary adjunctive therapy of childhood enuresis in children aged 6 years and olderPopulation: Children 6 years and olderDailyMed (U.S. National Library of Medicine)

• Anticholinergic effects (dry mouth, blurred vision, constipation, urinary retention), cardiovascular effects (orthostatic hypotension, tachycardia, arrhythmias, ECG changes), psychiatric effects (confusion especially in the elderly, insomnia, agitation) and neurological effects (tremor, paresthesia, seizures); withdrawal symptoms on abrupt cessation.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• In enuretic children the most common adverse reactions were nervousness, sleep disorders, tiredness and mild gastrointestinal disturbances.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Concomitant use of MAO inhibitors (allow at least 14 days when switching).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Acute recovery period after myocardial infarction.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Known hypersensitivity to imipramine (possible cross-sensitivity with other dibenzazepines).International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Boxed warning: antidepressants increased the risk of suicidal thinking and behavior in children, adolescents and young adults; monitor all patients for clinical worsening and suicidality. Imipramine is not approved for pediatric depression.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Use with extreme caution in cardiovascular disease (conduction defects, arrhythmias, heart failure, myocardial infarction, stroke, tachycardia), urinary retention, narrow-angle glaucoma (may trigger angle closure), a history of seizure disorder, and in hyperthyroid patients or those on thyroid medication (cardiovascular toxicity); screen for bipolar disorder before treatment.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Hyponatremia (risk greater in the elderly, with diuretics or volume depletion); discontinue before elective surgery as long as clinically possible; may enhance CNS depressant effects of alcohol.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• MAO inhibitorsHyperpyretic crises, severe convulsions and deaths reported; contraindicated.DailyMed (U.S. National Library of Medicine)
• CYP2D6 inhibitors (e.g. quinidine, cimetidine, SSRIs such as fluoxetine, sertraline, paroxetine; phenothiazines; propafenone, flecainide)May raise tricyclic plasma concentrations markedly; monitoring and dose adjustment may be needed.DailyMed (U.S. National Library of Medicine)
• Alcohol and other CNS depressantsEnhanced CNS depressant effects.DailyMed (U.S. National Library of Medicine)

• No well-controlled studies in pregnant women; clinical reports of congenital malformations (causality not established). Use in women who are or may become pregnant only if the clinical condition clearly justifies the potential fetal risk.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)
• Limited data suggest imipramine is likely excreted in breast milk; as a general rule a woman taking the drug should not nurse.International label, equivalent formulation · DailyMed (U.S. National Library of Medicine)

• Imipramine: Mechanism not definitely known; thought to potentiate adrenergic synapses by blocking norepinephrine reuptake at nerve endings.