سعر جرانيتيللين 25 مجم/5 مل شراب 120 مل 2022

Granityllin (amitriptyline 25 mg/5 ml) syrup, 120 ml, by Delta Grand Pharma (Grand Pharma); tricyclic antidepressant.

• Major depressive disorderPopulation: AdultsMHRA / electronic medicines compendium (emc)
• Neuropathic painPopulation: AdultsMHRA / electronic medicines compendium (emc)
• Prophylactic treatment of chronic tension-type headachePopulation: AdultsMHRA / electronic medicines compendium (emc)

• Very common: aggression, somnolence, tremor, dizziness, headache, drowsiness, speech disorder, accommodation disorder, palpitations, tachycardia (among others listed in the SmPC).International label, equivalent formulation · MHRA / electronic medicines compendium (emc)

• Hypersensitivity to amitriptyline or excipients; recent myocardial infarction; any degree of heart block, cardiac rhythm disorders or coronary artery insufficiency; severe liver disease; children under 6 years.International label, equivalent formulation · MHRA / electronic medicines compendium (emc)
• Concomitant MAOIs (risk of serotonin syndrome); start amitriptyline 14 days after irreversible non-selective MAOIs and at least 1 day after moclobemide; start MAOIs 14 days after stopping amitriptyline.International label, equivalent formulation · MHRA / electronic medicines compendium (emc)

• Cardiac arrhythmias and severe hypotension may occur, especially at high dosage or with heart disease; QT prolongation and arrhythmia reported—caution with bradycardia, uncompensated heart failure, QT-prolonging drugs and electrolyte disturbances.International label, equivalent formulation · MHRA / electronic medicines compendium (emc)
• Depression is associated with increased risk of suicidal thoughts and self-harm; monitor closely until significant improvement.International label, equivalent formulation · MHRA / electronic medicines compendium (emc)
• Use with caution in convulsive disorders, urinary retention, prostatic hypertrophy, hyperthyroidism, paranoid symptoms, advanced hepatic or cardiovascular disease, pyloric stenosis, paralytic ileus; may provoke acute angle-closure glaucoma in predisposed patients.International label, equivalent formulation · MHRA / electronic medicines compendium (emc)

• MAO inhibitors (non-selective, moclobemide, selegiline)Contraindicated: risk of serotonin syndrome.MHRA / electronic medicines compendium (emc)
• Sympathomimetics (adrenaline, ephedrine, noradrenaline, phenylephrine, etc.)Not recommended: amitriptyline may potentiate their cardiovascular effects.MHRA / electronic medicines compendium (emc)
• QT-prolonging drugs (e.g. quinidine, pimozide, sotalol, methadone) and hypokalaemia-inducing diureticsIncreased likelihood of ventricular arrhythmias / additive QT effects; use with caution.MHRA / electronic medicines compendium (emc)

• Limited clinical pregnancy data; animal reproductive toxicity. Not recommended in pregnancy unless clearly necessary after careful risk/benefit assessment.International label, equivalent formulation · MHRA / electronic medicines compendium (emc)
• Amitriptyline and metabolites are excreted in breast milk (0.6–1% of maternal dose); decide whether to stop breastfeeding or therapy.International label, equivalent formulation · MHRA / electronic medicines compendium (emc)

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