سعر ميتيانورمين 1000مجم 30 قرص 2023

Metianormin 1000 mg extended-release film-coated tablets, 30 per pack (Wadi Elneel Benta), containing metformin hydrochloride, a biguanide oral antidiabetic.

• Type 2 diabetes mellitus in adults, particularly overweight patients, when diet and exercise alone are inadequate; as monotherapy or with other oral antidiabetic agents or insulinPopulation: Adultselectronic medicines compendium (emc)
• Reduction in the risk or delay of the onset of type 2 diabetes in overweight adults with impaired glucose tolerance and/or impaired fasting glucose and/or increased HbA1c despite intensive lifestyle change for 3 to 6 monthsPopulation: Adultselectronic medicines compendium (emc)
• Polycystic ovary syndrome: ovulation stimulation to support conceptionPopulation: Adult womenelectronic medicines compendium (emc)

• Very common: gastrointestinal effects (nausea, vomiting, diarrhoea, abdominal pain, loss of appetite), mostly at initiation; common: taste disturbance and vitamin B12 decrease; very rare: lactic acidosis, hepatitis, skin reactions.International label, equivalent formulation · electronic medicines compendium (emc)

• Hypersensitivity; any acute metabolic acidosis (lactic acidosis, diabetic ketoacidosis); diabetic pre-coma; severe renal failure (GFR below 30 ml/min); acute conditions that may alter renal function (dehydration, severe infection, shock); diseases causing tissue hypoxia (decompensated heart failure, respiratory failure, recent myocardial infarction, shock); hepatic insufficiency, acute alcohol intoxication, alcoholism.International label, equivalent formulation · electronic medicines compendium (emc)

• Lactic acidosis is a very rare but serious complication, mostly with acute worsening of renal function, cardiorespiratory illness or sepsis; stop metformin temporarily in dehydration and seek medical advice if symptoms (acidotic dyspnoea, abdominal pain, muscle cramps, asthenia, hypothermia) occur.International label, equivalent formulation · electronic medicines compendium (emc)
• Discontinue before or at the time of iodinated contrast imaging and surgery under general, spinal or epidural anaesthesia; restart no earlier than 48 hours afterwards once renal function is stable.International label, equivalent formulation · electronic medicines compendium (emc)
• Metformin may reduce vitamin B12 levels, with risk increasing with dose and duration; monitor if deficiency (anaemia, neuropathy) is suspected.International label, equivalent formulation · electronic medicines compendium (emc)

• Alcohol and iodinated contrast agentsConcomitant use not recommended: alcohol intoxication increases lactic acidosis risk; stop metformin around iodinated contrast imaging.electronic medicines compendium (emc)
• NSAIDs, ACE inhibitors, angiotensin II receptor antagonists and diureticsMay impair renal function and increase lactic acidosis risk; monitor renal function closely.electronic medicines compendium (emc)
• OCT1/OCT2 inhibitors or inducers (e.g. verapamil, rifampicin, cimetidine, dolutegravir, ranolazine, trimethoprim)May alter metformin efficacy or renal elimination; use caution, especially in renal impairment.electronic medicines compendium (emc)

• Data from more than 1000 exposed pregnancies indicate no increased risk of congenital abnormalities or feto/neonatal toxicity; if clinically needed, metformin can be considered during pregnancy as an addition or alternative to insulin.International label, equivalent formulation · electronic medicines compendium (emc)
• Metformin is excreted into breast milk; no adverse effects were observed in breastfed infants, but because data are limited breastfeeding is not recommended during treatment.International label, equivalent formulation · electronic medicines compendium (emc)

• Metformin hydrochloride: Biguanide that reduces hepatic glucose production, facilitates peripheral glucose uptake and utilisation and alters glucose turnover in the gut; it does not stimulate insulin secretion and does not cause hypoglycaemia alone (UK SmPC). PubChem values refer to metformin base.